A molecular signature for delayed graft function

• Published in: Aging cell Vol. 17; no. 5; pp. e12825 - n/a
• Main Authors: McGuinness, Dagmara, Mohammed, Suhaib, Monaghan, Laura, Wilson, Paul A., Kingsmore, David B., Shapter, Oliver, Stevenson, Karen S., Coley, Shana M., Devey, Luke, Kirkpatrick, Robert B., Shiels, Paul G.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2018; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aging; Allografts; Alternative Splicing - genetics; Analysis; Cardiovascular diseases; Cellular Senescence - genetics; Chronic kidney failure; Cohort Studies; Delayed Graft Function - genetics; Delayed Graft Function - immunology; Delayed Graft Function - pathology; Diabetes mellitus; DNA methylation; Environmental factors; Epigenesis, Genetic; Epigenetics; Female; Gene expression; Gene Expression Profiling; Genomes; Humans; Inflammation; Kidney transplantation; Kidneys; Male; Middle Aged; Original; Perfusion; Phenotypes; Physiological aspects; Physiology; Proteomes; Pseudogenes; Renal failure; Reperfusion Injury - genetics; Reproducibility of Results; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sequence Analysis, RNA; Signal transduction; Transcription; Transplantation; Type 2 diabetes; γ-Interferon

Chronic kidney disease and associated comorbidities (diabetes, cardiovascular diseases) manifest with an accelerated ageing phenotype, leading ultimately to organ failure and renal replacement therapy. This process can be modulated by epigenetic and environmental factors which promote loss of physio...