Genome‐Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis

• Published in: Annals of neurology Vol. 90; no. 5; pp. 777 - 788
• Main Authors: Ken‐Dror, Gie, Cotlarciuc, Ioana, Martinelli, Ida, Grandone, Elvira, Hiltunen, Sini, Lindgren, Erik, Margaglione, Maurizio, Duchez, Veronique Le Cam, Triquenot, Aude Bagan, Zedde, Marialuisa, Mancuso, Michelangelo, Ruigrok, Ynte M., Marjot, Thomas, Worrall, Brad, Majersik, Jennifer J., Metso, Tiina M., Putaala, Jukka, Haapaniemi, Elena, Zuurbier, Susanna M., Brouwer, Matthijs C., Passamonti, Serena M., Abbattista, Maria, Bucciarelli, Paolo, Mitchell, Braxton D., Kittner, Steven J., Lemmens, Robin, Jern, Christina, Pappalardo, Emanuela, Costa, Paolo, Colombi, Marina, Sousa, Diana Aguiar, Rodrigues, Sofia, Canhão, Patrícia, Tkach, Aleksander, Santacroce, Rosa, Favuzzi, Giovanni, Arauz, Antonio, Colaizzo, Donatella, Spengos, Kostas, Hodge, Amanda, Ditta, Reina, Pezzini, Alessandro, Debette, Stephanie, Coutinho, Jonathan M., Thijs, Vincent, Jood, Katarina, Pare, Guillaume, Tatlisumak, Turgut, Ferro, José M., Sharma, Pankaj
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2021; Wiley Subscription Services, Inc; Wiley
• Subjects: ABO system; Adult; Blood group O; Blood groups; Confidence intervals; disease; Etiology; Genetic diversity; Genetic factors; Genetic Predisposition to Disease - genetics; Genetic variance; Genome-wide association studies; Genome-Wide Association Study; Genomes; Humans; Intracranial Thrombosis - genetics; Life Sciences; Linkage disequilibrium; Male; Middle Aged; Minority & ethnic groups; Neural coding; Neurologi; Neurology; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; Nucleotides; Risk; Risk Factors; Santé publique et épidémiologie; Single-nucleotide polymorphism; stroke; Thromboembolism; Thrombophilia; Thrombophilia - genetics; Thrombosis; Venous Thrombosis - genetics
• ISSN: 0364-5134; 1531-8249; 1531-8249
• DOI: 10.1002/ana.26205

Objective Cerebral venous thrombosis (CVT) is an uncommon form of stroke affecting mostly young individuals. Although genetic factors are thought to play a role in this cerebrovascular condition, its genetic etiology is not well understood. Methods A genome‐wide association study was performed to id...