Hematopoietic progenitor cell liabilities and alarmins S100A8/A9‐related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults

• Published in: Aging cell Vol. 21; no. 3; pp. e13545 - n/a
• Main Authors: Bonora, Benedetta Maria, Palano, Maria Teresa, Testa, Gianluca, Fadini, Gian Paolo, Sangalli, Elena, Madotto, Fabiana, Persico, Giuseppe, Casciaro, Francesca, Vono, Rosa, Colpani, Ornella, Scavello, Francesco, Cappellari, Roberta, Abete, Pasquale, Orlando, Patrizia, Carnelli, Franco, Berardi, Andrea Giovanni, De Servi, Stefano, Raucci, Angela, Giorgio, Marco, Madeddu, Paolo, Spinetti, Gaia
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2022; John Wiley and Sons Inc
• Subjects: Age; Aged; Alarmins; Bone marrow; Calgranulin A - genetics; Calgranulin A - metabolism; Calgranulin B - genetics; Calgranulin B - metabolism; Cardiovascular disease; Cardiovascular diseases; cardiovascular outcomes; Chronic illnesses; Cognitive ability; COVID-19; Cytokines; Cytokines - metabolism; Demographics; Enzyme-linked immunosorbent assay; Flow cytometry; Frailty; Frailty - genetics; Gene expression; Gene flow; Genotype & phenotype; Hematopoietic stem cells; Hematopoietic Stem Cells - metabolism; hematopoietic stem/progenitor cells; Humans; Hypertension; inflammaging; Inflammation; Liability (Law); Muscle strength; Older people; Original Paper; Peripheral blood; Phenotypes; Progenitor cells; Prognosis; Prospective Studies; RNA sequencing; Spirometry; Type 2 diabetes; hematopoietic stem/progenitor cells; frailty; inflammaging; cardiovascular outcomes; alarmins

Frailty affects the physical, cognitive, and social domains exposing older adults to an increased risk of cardiovascular disease and death. The mechanisms linking frailty and cardiovascular outcomes are mostly unknown. Here, we studied the association of abundance (flow cytometry) and gene expressio...