Hematopoietic progenitor cell liabilities and alarmins S100A8/A9‐related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults - Bonora, Benedetta Maria; Palano, Maria Teresa; Testa, Gianluca; Fadini, Gian Paolo; Sangalli, Elena; Madotto, Fabiana; Persico, Giuseppe; Casciaro, Francesca; Vono, Rosa; Colpani, Ornella; Scavello, Francesco; Cappellari, Roberta; et al. (Aging cell, 2022)
Keywords: Age; Aged; Alarmins; Bone marrow; Calgranulin A - genetics; Calgranulin A - metabolism; Calgranulin B - genetics; Calgranulin B - metabolism; Cardiovascular disease; Cardiovascular diseases; cardiovascular outcomes; Chronic illnesses; Cognitive ability; COVID-19; Cytokines; Cytokines - metabolism; Demographics; Enzyme-linked immunosorbent assay; Flow cytometry; Frailty; Frailty - genetics; Gene expression; Gene flow; Genotype & phenotype; Hematopoietic stem cells; Hematopoietic Stem Cells - metabolism; hematopoietic stem/progenitor cells; Humans; Hypertension; inflammaging; Inflammation; Liability (Law); Muscle strength; Older people; Original Paper; Peripheral blood; Phenotypes; Progenitor cells; Prognosis; Prospective Studies; RNA sequencing; Spirometry; Type 2 diabetes; hematopoietic stem/progenitor cells; frailty; inflammaging; cardiovascular outcomes; alarmins