Heat Shock Strengthens the Protective Potential of MSCs in Liver Injury by Promoting EV Release Through Upregulated Autophagosome Formation

• Published in: Journal of extracellular vesicles Vol. 14; no. 5; pp. e70084 - n/a
• Main Authors: Wang, Tingting, Gong, Yihang, Lin, Huizhu, Li, Xuejiao, Liang, Jinliang, Yuan, Xiaofeng, Li, Cuiping, Hu, Zhongying, Chen, Haitian, Xiao, Jiaqi, Zhang, Jiebin, Liu, Yasong, Yan, Xijing, Jiang, Chenhao, Yao, Jia, Zhang, Qi, Li, Rong, Zheng, Jun
• Format: Journal Article
• Language: English
• Published: United States John Wiley and Sons Inc 01.05.2025; Wiley
• Subjects: 14-3-3 Proteins - metabolism; Animals; Autophagosomes - metabolism; Autophagy; Autophagy-Related Protein-1 Homolog - metabolism; Extracellular Vesicles - metabolism; extracellular vesicles release; heat shock; Heat-Shock Response; Humans; Liver - injuries; Liver - metabolism; Male; mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mice; Mice, Inbred C57BL; Reperfusion Injury - metabolism; Reperfusion Injury - therapy; succinylation modification; TRPV2; Up-Regulation; TRPV2; heat shock; succinylation modification; mesenchymal stem cells; extracellular vesicles release

ABSTRACT Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) show powerful potential in the treatment of multiple diseases. However, the low yield of MSC‐EVs severely restricts their clinical application. Here, heat shock (HS), a moderate external stimulus, can enhance EVs release of MSCs...