Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis

• Published in: Cellular microbiology Vol. 10; no. 5; pp. 1027 - 1039
• Main Authors: Tobin, David M, Ramakrishnan, Lalita
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.05.2008; Blackwell Publishing Ltd; Hindawi Limited
• Subjects: Animals; Danio rerio; Host-Pathogen Interactions; Humans; Mycobacterium Infections - microbiology; Mycobacterium marinum; Mycobacterium marinum - genetics; Mycobacterium marinum - immunology; Mycobacterium marinum - pathogenicity; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - pathogenicity; Zebrafish

A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of...