Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis

A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of...

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Published in	Cellular microbiology Vol. 10; no. 5; pp. 1027 - 1039
Main Authors	Tobin, David M, Ramakrishnan, Lalita
Format	Journal Article
Language	English
Published	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.05.2008 Blackwell Publishing Ltd Hindawi Limited
Subjects	Animals Danio rerio Host-Pathogen Interactions Humans Mycobacterium Infections - microbiology Mycobacterium marinum Mycobacterium marinum - genetics Mycobacterium marinum - immunology Mycobacterium marinum - pathogenicity Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Zebrafish
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Abstract	A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of ectotherms. In this review, we present evidence that the similar genetic programmes of M. marinum and M. tuberculosis and the corresponding host immune responses reveal a conserved skeleton of Mycobacterium host-pathogen interactions. While both species have made niche-specific refinements, an essential framework has persisted. We highlight genetic comparisons of the two organisms and studies of M. marinum in the developing zebrafish. By pairing M. marinum with the simplified immune system of zebrafish embryos, many of the defining mechanisms of mycobacterial pathogenesis can be distilled and investigated in a tractable host/pathogen pair.
AbstractList	A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of ectotherms. In this review, we present evidence that the similar genetic programmes of M. marinum and M. tuberculosis and the corresponding host immune responses reveal a conserved skeleton of Mycobacterium host-pathogen interactions. While both species have made niche-specific refinements, an essential framework has persisted. We highlight genetic comparisons of the two organisms and studies of M. marinum in the developing zebrafish. By pairing M. marinum with the simplified immune system of zebrafish embryos, many of the defining mechanisms of mycobacterial pathogenesis can be distilled and investigated in a tractable host/pathogen pair. Summary A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of ectotherms. In this review, we present evidence that the similar genetic programmes of M. marinum and M. tuberculosis and the corresponding host immune responses reveal a conserved skeleton of Mycobacterium host–pathogen interactions. While both species have made niche‐specific refinements, an essential framework has persisted. We highlight genetic comparisons of the two organisms and studies of M. marinum in the developing zebrafish. By pairing M. marinum with the simplified immune system of zebrafish embryos, many of the defining mechanisms of mycobacterial pathogenesis can be distilled and investigated in a tractable host/pathogen pair.
Author	Tobin, David M Ramakrishnan, Lalita
Author_xml	– sequence: 1 fullname: Tobin, David M – sequence: 2 fullname: Ramakrishnan, Lalita
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18298637$$D View this record in MEDLINE/PubMed
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Snippet	A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each... Summary A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts,...
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SubjectTerms	Animals Danio rerio Host-Pathogen Interactions Humans Mycobacterium Infections - microbiology Mycobacterium marinum Mycobacterium marinum - genetics Mycobacterium marinum - immunology Mycobacterium marinum - pathogenicity Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Zebrafish
Title	Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
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