The spread of prions through the body in naturally acquired transmissible spongiform encephalopathies

• Published in: The FEBS journal Vol. 274; no. 3; pp. 588 - 605
• Main Authors: Beekes, Michael, McBride, Patricia A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2007
• Subjects: Animals; Cattle; Central Nervous System - metabolism; Central Nervous System - pathology; Creutzfeldt-Jakob Syndrome - metabolism; Creutzfeldt-Jakob Syndrome - pathology; Encephalopathy, Bovine Spongiform - metabolism; Encephalopathy, Bovine Spongiform - pathology; Humans; Models, Biological; naturally acquired TSEs; prion; prion diseases; Prion Diseases - metabolism; Prion Diseases - pathology; prion protein; prion routing; prion spread; Prions - metabolism; transmissible spongiform encephalopathies; Wasting Disease, Chronic - metabolism; Wasting Disease, Chronic - pathology

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases that are caused by unconventional pathogens and affect the central nervous system of animals and humans. Several different forms of these diseases result from natural infection (i.e. exposure to transmissible spongiform e...