Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis

• Published in: Inflammatory bowel diseases Vol. 17; no. 12; pp. 2407 - 2415
• Main Authors: Umeno, Junji, Asano, Kouichi, Matsushita, Tomonaga, Matsumoto, Takayuki, Kiyohara, Yutaka, Iida, Mitsuo, Nakamura, Yusuke, Kamatani, Naoyuki, Kubo, Michiaki
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford University Press 01.12.2011; Wiley Subscription Services, Inc., A Wiley Company
• Subjects: Case-Control Studies; Colitis, Ulcerative - genetics; Crohn Disease - genetics; Crohn's disease; Data processing; Environmental factors; Etiology; Genetic factors; Genetic Predisposition to Disease; Genome, Human; Genome-Wide Association Study; Genotype; Humans; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Meta-analysis; Polymorphism, Single Nucleotide - genetics; PTPN2 protein; Replication; Reviews; Risk Factors; shared genetic risk; Single-nucleotide polymorphism; Ulcerative colitis; meta-analysis; ulcerative colitis; Crohn's disease; shared genetic risk; single nucleotide polymorphism

Both ulcerative colitis (UC) and Crohn's disease (CD) have a complex etiology involving multiple genetic and environmental factors. Many genome-wide association studies (GWAS) and subsequent replication studies revealed that both diseases share some of the susceptibility loci; however, common g...