Biochemical Changes in Experimental Rat Brain Tumors Induced by Ethylnitrosourea and Human Gliomas after Dibutyryl Cyclic AMP Treatment

• Published in: Neurologia medico-chirurgica Vol. 22; no. 1; pp. 1 - 6
• Main Authors: SEIKI, Yoshikatsu, NAGASAWA, Sadatsugu, MATSUMOTO, Mikiro, SHIBATA, Iekado, TAKEZAWA, Junichi
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 1982; THE JAPAN NEUROSURGICAL SOCIETY
• Subjects: Animals; Antineoplastic Agents; Brain Neoplasms - drug therapy; Bucladesine - therapeutic use; cyclic AMP; dibutyryl 3', 5'-adenosine monophosphate (DBc-AMP); experimental brain tumor; free amino acids; Glioma - drug therapy; Humans; lysosomal enzyme; Neoplasms, Experimental - drug therapy; nucleic acids; Rats
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/nmc.22.1

Previous reports have shown that dibutyryl 3', 5'adenosine monophosphate (DBc-AMP) suppresses growth of actively dividing tumor cells, accelerates normalization of cellular metabolism and elevates the intracellular level of cyclic AMP. In an effort to study this mechanism further and defin...