Inhibition of Epithelial-Mesenchymal Transition and Metastasis by Combined TGFbeta Knockdown and Metformin Treatment in a Canine Mammary Cancer Xenograft Model

• Published in: Journal of mammary gland biology and neoplasia Vol. 22; no. 1; pp. 27 - 41
• Main Authors: Leonel, Camila, Borin, Thaiz Ferraz, de Carvalho Ferreira, Lívia, Moschetta, Marina Gobbe, Bajgelman, Marcio Chaim, Viloria-Petit, Alicia M., de Campos Zuccari, Debora Aparecida Pires
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2017; Springer Nature B.V
• Subjects: Animals; Cadherins - metabolism; Cancer Research; Cell Line, Tumor; Cell Movement - drug effects; Dogs; Epithelial-Mesenchymal Transition - drug effects; Mammary Neoplasms, Animal - drug therapy; Mammary Neoplasms, Animal - metabolism; Mammary Neoplasms, Animal - pathology; Medicine; Medicine & Public Health; Metformin - pharmacology; Neoplasm Invasiveness - pathology; Oncology; Transforming Growth Factor beta - metabolism; TGF-β; Breast cancer; Metastasis; shRNA; Anticarcinogenic agents

Epithelial mesenchymal transition (EMT) is a process by which epithelial cells acquire mesenchymal properties, generating metastases. Transforming growth factor beta (TGF-β) is associated with this malignancy by having the ability to induce EMT. Metformin, has been shown to inhibit EMT in breast can...