Microalgae for high-value products: A way towards green nutraceutical and pharmaceutical compounds

Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and pharmaceuticals. Moreover, the microalgal biomass contains carotenoids, vitamins, and other biomolecules that are widely used as food supplements. However,...

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Published inChemosphere (Oxford) Vol. 280; p. 130553
Main Authors Mehariya, Sanjeet, Goswami, Rahul Kumar, Karthikeysan, Obulisamy Parthiba, Verma, Pradeep
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2021
Subjects
biobased products
bioindustry
biomass production
biorefining
Carotenoids
commercialization
dietary supplements
drugs
environmental sustainability
Fatty acids
Genetic engineering
human health
Human health benefit
industrial applications
markets
Microalgae
Nutraceuticals
renewable resources
supply balance
Microalgae
Genetic engineering
Carotenoids
Human health benefit
Fatty acids
Nutraceuticals
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Abstract Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and pharmaceuticals. Moreover, the microalgal biomass contains carotenoids, vitamins, and other biomolecules that are widely used as food supplements. However, the microalgal biomass production, their composition variations, energy-intensive harvesting methods, optimized bio-refinery routes, and lack of techno-economic analysis are the major bottleneck for the life-sized commercialization of this nascent bio-industry. This review discusses the microalgae-derived key bioactive compounds and their applications in different sectors for human health. Furthermore, this review proposes advanced strategies to enhance the productivity of bioactive compounds and highlight the key challenges associated with a safety issue for use of microalgae biomass. It also provides a detailed global scenario and market demand of microalgal bioproducts. In conclusion, this review will provide the concept of microalgal biorefinery to produce bioactive compounds at industrial scale platform for their application in the nutraceutical and pharmaceutical sector considering their current and future market trends. [Display omitted] •Microalgae are bio-factory that produces high value-added compounds (HVAC) from CO2.•Bioprospecting of microalgae strain enhances biomass yield and HVAC contents.•Genetic engineering boosts the accumulation of HVAC in microalgae.•Microalgae HVAC have nutraceuticals, cosmeceutical and pharmaceutical applications.•High demands for algal HVAC help to develop and sustain the circular bioeconomy.
AbstractList Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and pharmaceuticals. Moreover, the microalgal biomass contains carotenoids, vitamins, and other biomolecules that are widely used as food supplements. However, the microalgal biomass production, their composition variations, energy-intensive harvesting methods, optimized bio-refinery routes, and lack of techno-economic analysis are the major bottleneck for the life-sized commercialization of this nascent bio-industry. This review discusses the microalgae-derived key bioactive compounds and their applications in different sectors for human health. Furthermore, this review proposes advanced strategies to enhance the productivity of bioactive compounds and highlight the key challenges associated with a safety issue for use of microalgae biomass. It also provides a detailed global scenario and market demand of microalgal bioproducts. In conclusion, this review will provide the concept of microalgal biorefinery to produce bioactive compounds at industrial scale platform for their application in the nutraceutical and pharmaceutical sector considering their current and future market trends.
Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and pharmaceuticals. Moreover, the microalgal biomass contains carotenoids, vitamins, and other biomolecules that are widely used as food supplements. However, the microalgal biomass production, their composition variations, energy-intensive harvesting methods, optimized bio-refinery routes, and lack of techno-economic analysis are the major bottleneck for the life-sized commercialization of this nascent bio-industry. This review discusses the microalgae-derived key bioactive compounds and their applications in different sectors for human health. Furthermore, this review proposes advanced strategies to enhance the productivity of bioactive compounds and highlight the key challenges associated with a safety issue for use of microalgae biomass. It also provides a detailed global scenario and market demand of microalgal bioproducts. In conclusion, this review will provide the concept of microalgal biorefinery to produce bioactive compounds at industrial scale platform for their application in the nutraceutical and pharmaceutical sector considering their current and future market trends.Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and pharmaceuticals. Moreover, the microalgal biomass contains carotenoids, vitamins, and other biomolecules that are widely used as food supplements. However, the microalgal biomass production, their composition variations, energy-intensive harvesting methods, optimized bio-refinery routes, and lack of techno-economic analysis are the major bottleneck for the life-sized commercialization of this nascent bio-industry. This review discusses the microalgae-derived key bioactive compounds and their applications in different sectors for human health. Furthermore, this review proposes advanced strategies to enhance the productivity of bioactive compounds and highlight the key challenges associated with a safety issue for use of microalgae biomass. It also provides a detailed global scenario and market demand of microalgal bioproducts. In conclusion, this review will provide the concept of microalgal biorefinery to produce bioactive compounds at industrial scale platform for their application in the nutraceutical and pharmaceutical sector considering their current and future market trends.
Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and pharmaceuticals. Moreover, the microalgal biomass contains carotenoids, vitamins, and other biomolecules that are widely used as food supplements. However, the microalgal biomass production, their composition variations, energy-intensive harvesting methods, optimized bio-refinery routes, and lack of techno-economic analysis are the major bottleneck for the life-sized commercialization of this nascent bio-industry. This review discusses the microalgae-derived key bioactive compounds and their applications in different sectors for human health. Furthermore, this review proposes advanced strategies to enhance the productivity of bioactive compounds and highlight the key challenges associated with a safety issue for use of microalgae biomass. It also provides a detailed global scenario and market demand of microalgal bioproducts. In conclusion, this review will provide the concept of microalgal biorefinery to produce bioactive compounds at industrial scale platform for their application in the nutraceutical and pharmaceutical sector considering their current and future market trends. [Display omitted] •Microalgae are bio-factory that produces high value-added compounds (HVAC) from CO2.•Bioprospecting of microalgae strain enhances biomass yield and HVAC contents.•Genetic engineering boosts the accumulation of HVAC in microalgae.•Microalgae HVAC have nutraceuticals, cosmeceutical and pharmaceutical applications.•High demands for algal HVAC help to develop and sustain the circular bioeconomy.
ArticleNumber 130553
Author Mehariya, Sanjeet
Karthikeysan, Obulisamy Parthiba
Goswami, Rahul Kumar
Verma, Pradeep
Author_xml – sequence: 1
  givenname: Sanjeet
  surname: Mehariya
  fullname: Mehariya, Sanjeet
  organization: Department of Engineering, University of Campania “Luigi Vanvitelli”, Real Casa Dell’Annunziata, Via Roma 29, 81031, Aversa, CE, Italy
– sequence: 2
  givenname: Rahul Kumar
  orcidid: 0000-0002-8270-214X
  surname: Goswami
  fullname: Goswami, Rahul Kumar
  organization: Bioprocess and Bioenergy Laboratory, Department of Microbiology, Central University of Rajasthan, NH-8, Bandarsindri, Kishangarh, Ajmer, 305817, Rajasthan, India
– sequence: 3
  givenname: Obulisamy Parthiba
  surname: Karthikeysan
  fullname: Karthikeysan, Obulisamy Parthiba
  email: opkens@gmail.com
  organization: Department of Engineering Technology, College of Technology, University of Houston, Houston, TX, USA
– sequence: 4
  givenname: Pradeep
  surname: Verma
  fullname: Verma, Pradeep
  email: pradeepverma@curaj.ac.in
  organization: Bioprocess and Bioenergy Laboratory, Department of Microbiology, Central University of Rajasthan, NH-8, Bandarsindri, Kishangarh, Ajmer, 305817, Rajasthan, India
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33940454$$D View this record in MEDLINE/PubMed
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-183124$$DView record from Swedish Publication Index
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  article-title: Advances and challenges in genetic engineering of microalgae
  publication-title: Rev. Aquacult.
  doi: 10.1111/raq.12322
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Snippet Microalgae is a renewable bioresource with the potential to replace the conventional fossil-based industrial production of organic chemicals and...
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SubjectTerms biobased products
bioindustry
biomass production
biorefining
Carotenoids
commercialization
dietary supplements
drugs
environmental sustainability
Fatty acids
Genetic engineering
human health
Human health benefit
industrial applications
markets
Microalgae
Nutraceuticals
renewable resources
supply balance
Title Microalgae for high-value products: A way towards green nutraceutical and pharmaceutical compounds
URI https://dx.doi.org/10.1016/j.chemosphere.2021.130553
https://www.ncbi.nlm.nih.gov/pubmed/33940454
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Volume 280
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