Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study

Abstract Background Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors as...

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Published inThe Journal of Infectious Diseases Vol. 217; no. 3; pp. 418 - 427
Main Authors Sarna, Mohinder, Ware, Robert S, Lambert, Stephen B, Sloots, Theo P, Nissen, Michael D, Grimwood, Keith
Format Journal Article Web Resource
LanguageEnglish
Published US Oxford University Press 17.01.2018
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Abstract Abstract Background Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors associated with increased odds of symptomatic fVDEs. Methods The Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday. Parents recorded daily symptoms and collected nose swabs weekly, which were batch-tested using polymerase chain reaction assays for 17 respiratory viruses. Results One hundred fifty-eight infants participated in ORChID. The median age for fVDEs was 2.9 months for human rhinovirus (HRV) but was ≥13.9 months for other respiratory viruses. Overall, 52% of HRV fVDEs were symptomatic, compared with 57%–83% of other fVDEs. Respiratory syncytial virus and human metapneumovirus fVDEs were more severe than HRV fVDEs. Older age and the winter season were associated with symptomatic episodes. Conclusions Infants do not always experience respiratory symptoms with their fVDE. Predominance of early HRV detections highlights the need for timing any intervention early in life. fVDEs from other respiratory viruses most commonly occur when maternal vaccines may no longer provide protection.
AbstractList Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors associated with increased odds of symptomatic fVDEs. The Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday. Parents recorded daily symptoms and collected nose swabs weekly, which were batch-tested using polymerase chain reaction assays for 17 respiratory viruses. One hundred fifty-eight infants participated in ORChID. The median age for fVDEs was 2.9 months for human rhinovirus (HRV) but was ≥13.9 months for other respiratory viruses. Overall, 52% of HRV fVDEs were symptomatic, compared with 57%-83% of other fVDEs. Respiratory syncytial virus and human metapneumovirus fVDEs were more severe than HRV fVDEs. Older age and the winter season were associated with symptomatic episodes. Infants do not always experience respiratory symptoms with their fVDE. Predominance of early HRV detections highlights the need for timing any intervention early in life. fVDEs from other respiratory viruses most commonly occur when maternal vaccines may no longer provide protection.
Abstract Background Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors associated with increased odds of symptomatic fVDEs. Methods The Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday. Parents recorded daily symptoms and collected nose swabs weekly, which were batch-tested using polymerase chain reaction assays for 17 respiratory viruses. Results One hundred fifty-eight infants participated in ORChID. The median age for fVDEs was 2.9 months for human rhinovirus (HRV) but was ≥13.9 months for other respiratory viruses. Overall, 52% of HRV fVDEs were symptomatic, compared with 57%–83% of other fVDEs. Respiratory syncytial virus and human metapneumovirus fVDEs were more severe than HRV fVDEs. Older age and the winter season were associated with symptomatic episodes. Conclusions Infants do not always experience respiratory symptoms with their fVDE. Predominance of early HRV detections highlights the need for timing any intervention early in life. fVDEs from other respiratory viruses most commonly occur when maternal vaccines may no longer provide protection.
BackgroundDetermining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive interventions, including vaccination. We describe the ages and nature of fVDEs in an infant birth cohort and explore factors associated with increased odds of symptomatic fVDEs. MethodsThe Observational Research in Childhood Infectious Diseases (ORChID) study is a community-based birth cohort describing acute respiratory infections in infants until their second birthday. Parents recorded daily symptoms and collected nose swabs weekly, which were batch-tested using polymerase chain reaction assays for 17 respiratory viruses. ResultsOne hundred fifty-eight infants participated in ORChID. The median age for fVDEs was 2.9 months for human rhinovirus (HRV) but was ≥13.9 months for other respiratory viruses. Overall, 52% of HRV fVDEs were symptomatic, compared with 57%-83% of other fVDEs. Respiratory syncytial virus and human metapneumovirus fVDEs were more severe than HRV fVDEs. Older age and the winter season were associated with symptomatic episodes. ConclusionsInfants do not always experience respiratory symptoms with their fVDE. Predominance of early HRV detections highlights the need for timing any intervention early in life. fVDEs from other respiratory viruses most commonly occur when maternal vaccines may no longer provide protection.
Author Sarna, Mohinder
Nissen, Michael D
Ware, Robert S
Sloots, Theo P
Grimwood, Keith
Lambert, Stephen B
AuthorAffiliation 4 School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast
1 School of Public Health, University of Queensland, Brisbane
3 Menzies Health Institute Queensland, Griffith University, Gold Coast
2 UQ Child Health Research Centre, School of Medicine, University of Queensland, Brisbane
5 Departments of Infectious Diseases and Paediatrics, Gold Coast Health, Queensland, Australia
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Issue 3
Keywords human rhinovirus
cohort study
primary infection
respiratory viruses
infant
human metapneumovirus
respiratory syncytial virus
Language English
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Snippet Abstract Background Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and...
Determining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs preventive...
BackgroundDetermining timing of first virus detection episodes (fVDEs) for different respiratory viruses in infants identifies risk periods and informs...
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SubjectTerms Age Factors
Cohort Studies
Community-Acquired Infections - epidemiology
Community-Acquired Infections - pathology
Community-Acquired Infections - virology
Editor's Choice
Female
Humans
Infant
Infant, Newborn
Major and Brief Reports
Male
Nasal Cavity - virology
Polymerase Chain Reaction
Pregnancy
Prevalence
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - pathology
Respiratory Tract Infections - virology
Risk Factors
Virus Diseases - epidemiology
Virus Diseases - pathology
Virus Diseases - virology
Viruses - classification
Viruses - isolation & purification
Title Timing of First Respiratory Virus Detections in Infants: A Community-Based Birth Cohort Study
URI https://www.ncbi.nlm.nih.gov/pubmed/29165576
https://www.proquest.com/docview/2406230063
https://search.proquest.com/docview/1967464602
https://pubmed.ncbi.nlm.nih.gov/PMC7107408
Volume 217
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