Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients

• Published in: Biomedicines Vol. 12; no. 5; p. 1022
• Main Authors: Zhdanov, Dmitry D., Gladilina, Yulia A., Blinova, Varvara G., Abramova, Anna A., Shishparenok, Anastasia N., Eliseeva, Daria D.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Alternative splicing; Amyotrophic lateral sclerosis; Antibodies; Apoptosis; Autoimmune diseases; CD25 antigen; CD4 antigen; Cell therapy; CTLA-4 protein; Development and progression; Disease; Endopeptidases; Ethylenediaminetetraacetic acid; Exons; Flow cytometry; Forkhead protein; FoxP3; Foxp3 protein; Gene expression; Immunoregulation; Lymphocytes; Lymphocytes T; Medical prognosis; Messenger RNA; Oligonucleotides; Perforin; Peripheral blood; Proteins; regulatory T cells; Serine proteinase; splicing-switching oligonucleotides; suppressive activity; T cells; Telomerase; Transcription factors; Germany; Russia; United States > US; regulatory T cells; splicing-switching oligonucleotides; alternative splicing; FoxP3; amyotrophic lateral sclerosis; suppressive activity

Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development, maturation, and function of regulatory T cells (Tregs). The FoxP3 pre-mRNA is subject to alternative splicing, resulting in the translation of multiple splice variants. We have shown that Tregs from patient...