Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

• Published in: American journal of respiratory and critical care medicine Vol. 181; no. 4; pp. 315 - 323
• Main Authors: Moore, Wendy C, Meyers, Deborah A, Wenzel, Sally E, Teague, W. Gerald, Li, Huashi, Li, Xingnan, D'Agostino, Ralph, Jr, Castro, Mario, Curran-Everett, Douglas, Fitzpatrick, Anne M, Gaston, Benjamin, Jarjour, Nizar N, Sorkness, Ronald, Calhoun, William J, Chung, Kian Fan, Comhair, Suzy A. A, Dweik, Raed A, Israel, Elliot, Peters, Stephen P, Busse, William W, Erzurum, Serpil C, Bleecker, Eugene R, National Heart, Lung, and Blood Institute's Severe Asthma Research Program
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.02.2010; American Thoracic Society
• Subjects: Adolescent; Adrenal Cortex Hormones - therapeutic use; Adult; Age Factors; Age of Onset; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Asthmatic Agents - therapeutic use; Asthma; Asthma - classification; Asthma - drug therapy; Asthma - physiopathology; B. Asthma and Allergy; Biological and medical sciences; Biomarkers; Bronchodilator Agents - therapeutic use; Child; Chronic obstructive pulmonary disease, asthma; Cluster Analysis; Cohort Studies; Discriminant Analysis; Female; Health services utilization; Humans; Infections; Intensive care medicine; Male; Medical sciences; Middle Aged; Phenotype; Pneumology; Questionnaires; Respiratory Function Tests; Sex Factors; Steroids; Variables; Young Adult; Lung disease; Intensive care; Respiratory disease; Asthma; Phenotype; Research program; asthma phenotype; severe asthma; Bronchus disease; definition; Obstructive pulmonary disease; cluster analysis; Resuscitation

The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. To identify novel asthma phenotypes using an unsupervised hierarchical clust...