Neurogenic orthostatic hypotension: A double-blind, placebo-controlled study with midodrine

• Published in: The American journal of medicine Vol. 95; no. 1; pp. 38 - 48
• Main Authors: Jankovic, Joseph, Gilden, Janice L., Hiner, Bradley C., Kaufmann, Horacio, Brown, David C., Coghlan, Cecil H., Rubin, Michael, Fouad-Tarazi, Fetnat M.
• Format: Journal Article
• Language: English
• Published: Legacy CDMS Elsevier Inc 01.07.1993; Elsevier; Elsevier Sequoia S.A
• Subjects: Adult; Aerospace Medicine; Aged; Aged, 80 and over; Autonomic Nervous System Diseases - complications; Biological and medical sciences; Blood pressure; Cardiovascular system; Double-Blind Method; Drug therapy; Female; Humans; Hypotension, Orthostatic - drug therapy; Hypotension, Orthostatic - etiology; Male; Medical research; Medical sciences; Middle Aged; Midodrine - adverse effects; Midodrine - therapeutic use; Pharmacology. Drug treatments; Vascular wall; Nasa Discipline Cardiopulmonary; Clinical Trial; Nasa Discipline Number 14-10; Nasa Program Space Physiology And Countermeasures; Non-Nasa Center; Multicenter Study; Randomized Controlled Trial; Human; Postural hypotension; Chemotherapy; Treatment; Diseases of the autonomic nervous system; Double blind study; Cardiovascular disease; Result; NASA Discipline Cardiopulmonary; NASA Program Space Physiology and Countermeasures; NASA Discipline Number 14-10; Non-NASA Center

purpose: To investigate the efficacy and safety of midodrine for treatment of patients with orthostatic hypotension due to autonomic failure. patients: Ninety-seven patients with orthostatic hypotension were randomized in a 4-week, double-blinded, placebo-controlled study with a 1-week placebo run-i...