Gene expression profiling in the lungs of phenylhydrazine-treated rats: The contribution of pro-inflammatory response and endothelial dysfunction to acute thrombosis

• Published in: Experimental and Toxicologic Pathology Vol. 67; no. 2; pp. 205 - 210
• Main Authors: Sato, Hiroko, Terasaki, Natsuko, Sakairi, Tetsuya, Tanaka, Masaharu, Takahashi, Kimimasa
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.02.2015; Elsevier BV
• Subjects: Acute Disease; Acute thrombosis; adhesion; Animals; anticoagulants; blood coagulation; coagulation; endothelial cells; Endothelial dysfunction; Endothelium, Vascular; Endothelium, Vascular - drug effects; Endothelium, Vascular - immunology; Endothelium, Vascular - pathology; Gene Expression Profiling; gene expression regulation; Gene Ontology; genes; hemostasis; histopathology; immune response; Inflammation; Lung; Lung - drug effects; Lung - immunology; Lung - metabolism; Lung - pathology; lungs; Male; males; Microarray Analysis; microarray technology; pathogenesis; Phenylhydrazine (PHZ); Phenylhydrazines; Phenylhydrazines - toxicity; Pulmonary Embolism; Pulmonary Embolism - chemically induced; Pulmonary Embolism - genetics; Pulmonary Embolism - immunology; Pulmonary Embolism - pathology; Rat; rats; Rats, Sprague-Dawley; risk factors; thromboplastin; thrombosis; Transcriptome; Transcriptome - drug effects; Up-Regulation; Endothelial dysfunction; Inflammation; Acute thrombosis; Rat; Lung; Phenylhydrazine (PHZ)

Pulmonary thrombosis is a life-threatening disorder caused by various risk factors. We previously reported that phenylhydrazine (PHZ) induces acute thrombosis in the rat lung, with regional stasis in the alveolar capillaries as a trigger, and subsequent hemostatic disruption is involved as an accele...