Direct molecular interactions between HMGB1 and TP53 in colorectal cancer

• Published in: Autophagy Vol. 8; no. 5; pp. 846 - 848
• Main Authors: Livesey, Kristen M., Kang, Rui, Zeh, III, Herbert J., Lotze, Michael T., Tang, Daolin
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.05.2012; Landes Bioscience
• Subjects: Apoptosis; Autophagic Punctum; Autophagy; Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cell Nucleus - metabolism; Cell Survival; colorectal cancer; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Cycle; Cytosol - metabolism; HMGB1; HMGB1 Protein - metabolism; Humans; Landes; Models, Biological; Organogenesis; Protein Binding; Proteins; Subcellular Fractions - metabolism; TP53; Tumor Suppressor Protein p53 - metabolism

Tumorigenesis and the efficacy of cancer therapeutics are both defined by the balance between autophagy and apoptosis. High-mobility group box 1 (HMGB1) is a DNA chaperone and extracellular damage-associated molecular pattern molecule (DAMP) with pro-autophagic activity. TP53/p53 plays a transcripti...