T-lymphocyte CREB as a potential biomarker of response to antidepressant drugs

• Published in: The international journal of neuropsychopharmacology Vol. 16; no. 5; pp. 967 - 974
• Main Authors: Lim, Shinn-Won, Kim, Seonwoo, Carroll, Bernard J., Kim, Doh Kwan
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.06.2013; Oxford University Press
• Subjects: Aged; Aged, 80 and over; Antidepressants; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Biomarkers; CD3 Complex - metabolism; Cyclic AMP; Cyclic AMP Response Element-Binding Protein - metabolism; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - pathology; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; ROC Curve; Serotonin Uptake Inhibitors - pharmacology; T-Lymphocytes - drug effects; T-Lymphocytes - metabolism; Antidepressant; CREB; peripheral lymphocyte; depression; biomarker

Response to drug treatment of major depression is variable and biomarkers of response are needed. Cyclic AMP response element binding protein (CREB) is considered a key mediator of antidepressant drug effect. We studied CREB in T-lymphocytes as a potential predictor of response to a selective seroto...