Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression

• Published in: Toxins Vol. 8; no. 1; p. 1
• Main Authors: Zhang, Zhang, Zhang, Yan, Shi, Minglei, Ye, Bingyu, Shen, Wenlong, Li, Ping, Xing, Lingyue, Zhang, Xiaopeng, Hou, Lihua, Xu, Junjie, Zhao, Zhihu, Chen, Wei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.12.2015; MDPI
• Subjects: anthrax toxin; Antigens, Bacterial - toxicity; ANTXR2; Bacterial Toxins - toxicity; Cell Line; Communication; Enhancer Elements, Genetic; Gene mapping; gene structure; gene transcription; Genetic diversity; genetic polymorphism; Genetic Predisposition to Disease; Genetic Variation; HEK293 Cells; Humans; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, Peptide - genetics; Toxins; anthrax toxin; gene structure; gene transcription; ANTXR2; genetic polymorphism

Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. Previous studies found that ANTXR2 transcript abundance varies considerably in individuals of different ethnic/geographical groups, but no e...