Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression

Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. Previous studies found that ANTXR2 transcript abundance varies considerably in individuals of different ethnic/geographical groups, but no e...

Full description

Saved in:
Bibliographic Details
Published inToxins Vol. 8; no. 1; p. 1
Main Authors Zhang, Zhang, Zhang, Yan, Shi, Minglei, Ye, Bingyu, Shen, Wenlong, Li, Ping, Xing, Lingyue, Zhang, Xiaopeng, Hou, Lihua, Xu, Junjie, Zhao, Zhihu, Chen, Wei
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.12.2015
MDPI
Subjects
anthrax toxin
Antigens, Bacterial - toxicity
ANTXR2
Bacterial Toxins - toxicity
Cell Line
Communication
Enhancer Elements, Genetic
Gene mapping
gene structure
gene transcription
Genetic diversity
genetic polymorphism
Genetic Predisposition to Disease
Genetic Variation
HEK293 Cells
Humans
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Receptors, Peptide - genetics
Toxins
anthrax toxin
gene structure
gene transcription
ANTXR2
genetic polymorphism
Online AccessGet full text

Cover

Abstract Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. Previous studies found that ANTXR2 transcript abundance varies considerably in individuals of different ethnic/geographical groups, but no eQTLs (expression quantitative trait loci) have been identified. By using 3C (chromatin conformation capture), CRISPR-mediated genomic deletion and dual-luciferase reporter assay, gene loci containing cis-regulatory elements of ANTXR2 were localized. Two SNPs (single nucleotide polymorphism) at the conserved CREB-binding motif, rs13140055 and rs80314910 in the promoter region of the gene, modulating ANTXR2 promoter activity were identified. Combining these two regulatory SNPs with a previously reported SNP, rs12647691, for the first time, a statistically significant correlation between human genetic variations and anthrax toxin sensitivity was observed. These findings further our understanding of human variability in ANTXR2 expression and anthrax toxin susceptibility.
AbstractList Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. Previous studies found that ANTXR2 transcript abundance varies considerably in individuals of different ethnic/geographical groups, but no eQTLs (expression quantitative trait loci) have been identified. By using 3C (chromatin conformation capture), CRISPR-mediated genomic deletion and dual-luciferase reporter assay, gene loci containing cis-regulatory elements of ANTXR2 were localized. Two SNPs (single nucleotide polymorphism) at the conserved CREB-binding motif, rs13140055 and rs80314910 in the promoter region of the gene, modulating ANTXR2 promoter activity were identified. Combining these two regulatory SNPs with a previously reported SNP, rs12647691, for the first time, a statistically significant correlation between human genetic variations and anthrax toxin sensitivity was observed. These findings further our understanding of human variability in ANTXR2 expression and anthrax toxin susceptibility.
Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. Previous studies found that ANTXR2 transcript abundance varies considerably in individuals of different ethnic/geographical groups, but no eQTLs (expression quantitative trait loci) have been identified. By using 3C (chromatin conformation capture), CRISPR-mediated genomic deletion and dual-luciferase reporter assay, gene loci containing cis-regulatory elements of ANTXR2 were localized. Two SNPs (single nucleotide polymorphism) at the conserved CREB-binding motif, rs13140055 and rs80314910 in the promoter region of the gene, modulating ANTXR2 promoter activity were identified. Combining these two regulatory SNPs with a previously reported SNP, rs12647691, for the first time, a statistically significant correlation between human genetic variations and anthrax toxin sensitivity was observed. These findings further our understanding of human variability in ANTXR2 expression and anthrax toxin susceptibility.
Author Chen, Wei
Ye, Bingyu
Xing, Lingyue
Li, Ping
Shi, Minglei
Zhao, Zhihu
Zhang, Xiaopeng
Shen, Wenlong
Zhang, Yan
Hou, Lihua
Zhang, Zhang
Xu, Junjie
AuthorAffiliation Beijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China; zzhnng@yeah.net (Z.Z.); zany1983@163.com (Y.Z.); shiml79@126.com (M.S.); byy0804@gmail.com (B.Y.); shenwl1988@gmail.com (W.S.); lipingtry@163.com (P.L.); xinglyinfo@163.com (L.X.); zxp8565@aliyun.com (X.Z.); houlihua@sina.com (L.H.)
AuthorAffiliation_xml – name: Beijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China; zzhnng@yeah.net (Z.Z.); zany1983@163.com (Y.Z.); shiml79@126.com (M.S.); byy0804@gmail.com (B.Y.); shenwl1988@gmail.com (W.S.); lipingtry@163.com (P.L.); xinglyinfo@163.com (L.X.); zxp8565@aliyun.com (X.Z.); houlihua@sina.com (L.H.)
Author_xml – sequence: 1
  givenname: Zhang
  surname: Zhang
  fullname: Zhang, Zhang
– sequence: 2
  givenname: Yan
  surname: Zhang
  fullname: Zhang, Yan
– sequence: 3
  givenname: Minglei
  surname: Shi
  fullname: Shi, Minglei
– sequence: 4
  givenname: Bingyu
  orcidid: 0000-0001-9376-2861
  surname: Ye
  fullname: Ye, Bingyu
– sequence: 5
  givenname: Wenlong
  orcidid: 0000-0002-2293-5590
  surname: Shen
  fullname: Shen, Wenlong
– sequence: 6
  givenname: Ping
  surname: Li
  fullname: Li, Ping
– sequence: 7
  givenname: Lingyue
  surname: Xing
  fullname: Xing, Lingyue
– sequence: 8
  givenname: Xiaopeng
  surname: Zhang
  fullname: Zhang, Xiaopeng
– sequence: 9
  givenname: Lihua
  surname: Hou
  fullname: Hou, Lihua
– sequence: 10
  givenname: Junjie
  surname: Xu
  fullname: Xu, Junjie
– sequence: 11
  givenname: Zhihu
  surname: Zhao
  fullname: Zhao, Zhihu
– sequence: 12
  givenname: Wei
  surname: Chen
  fullname: Chen, Wei
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26703731$$D View this record in MEDLINE/PubMed
BookMark eNptkktv1DAURiNUREvpki2KxIZNil9JbBZIo6q0lQpUUCR2ll-Z8SixU9tBM_--DtOiTsXKr-OjT_fe18WB884UxVsITjFm4GPyG-siBRAAAF8URwi0qGqaGh482R8WJzGuMwEwhgy2r4pD1LQAtxgeFTcLl1ZBbMqfU1RmTFba3qbtp_JyGoQrL4wzyaryxvfbwYdxZeMQy69eT71I1i3Lxbfb3z9Qeb4Zg4nRevemeNmJPpqTh_W4-PXl_Pbssrr-fnF1triuVA1JqqQwREkFG9JAZuqO6FYASjUU8wl2UFBKoGEtaojsjIIISyaRNhAKpFWNj4urnVd7seZjsIMIW-6F5X8vfFhyEXL03nBDJaoZVVggQmitmZad6jTVtdFEstn1eecaJzkYrYxLQfR70v0XZ1d86f9w0iJaI5wFHx4Ewd9NJiY-2FzOvhfO-Cly2DYI55pDmtH3z9C1n4LLpZopkhvEAMvUu6eJ_kV5bFwG8A5QwccYTMeVTbklfg5oew4BnyeE701I_lU9-_Uo_j9_DxRqv4A
CitedBy_id crossref_primary_10_1016_j_jfutfo_2022_03_002
crossref_primary_10_1016_j_jpba_2024_116253
crossref_primary_10_3920_WMJ2020_2572
crossref_primary_10_1021_acssynbio_2c00214
crossref_primary_10_1080_15427528_2020_1808133
crossref_primary_10_3920_WMJ2018_2340
crossref_primary_10_1016_j_toxicon_2019_06_022
crossref_primary_10_3920_WMJ2017_2283
crossref_primary_10_3920_WMJ2020_2559
crossref_primary_10_1016_j_toxicon_2020_01_007
crossref_primary_10_1016_j_foodres_2017_09_080
crossref_primary_10_3390_genes15040426
Cites_doi 10.1007/978-1-60327-461-6_7
10.1073/pnas.1302257110
10.1073/pnas.1121006109
10.1128/IAI.05947-11
10.1016/j.bbamcr.2014.12.002
10.1093/nar/gkt067
10.1016/j.micpath.2006.05.001
10.1073/pnas.0905409106
10.1038/ng1966
10.1038/nature12510
10.1073/pnas.0407794101
10.1073/pnas.0710100105
10.1038/ng.513
10.1146/annurev.biochem.75.103004.142728
10.1111/j.1365-2958.2011.07770.x
10.1126/science.1242088
10.1111/j.1365-2958.2006.05232.x
10.3390/toxins5010001
10.1126/science.1232033
10.1016/j.cell.2005.12.045
10.1042/BJ20061891
10.1016/j.tim.2014.02.012
10.1038/nprot.2008.68
10.1073/pnas.0431098100
10.1038/emboj.2011.442
10.3109/03009742.2011.600700
10.1038/nbt.2808
10.1038/nbt.2842
10.1038/n35101999
10.1128/IAI.05070-11
10.1038/nature13138
10.1101/gr.5704207
10.1016/j.chom.2010.10.004
10.1093/nar/gkh383
10.1038/nprot.2013.143
10.1093/nar/gkr1055
10.1074/jbc.M109.065813
10.1038/nature11233
10.1038/nrg3686
10.1016/S0076-6879(03)75030-7
ContentType Journal Article
Copyright Copyright MDPI AG 2016
2015 by the authors; licensee MDPI, Basel, Switzerland. 2015
Copyright_xml – notice: Copyright MDPI AG 2016
– notice: 2015 by the authors; licensee MDPI, Basel, Switzerland. 2015
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7T7
7U7
7X7
7XB
88E
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ATCPS
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
P64
PATMY
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PYCSY
RC3
5PM
DOA
DOI 10.3390/toxins8010001
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Toxicology Abstracts
Health & Medical Collection (ProQuest)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central Database Suite (ProQuest)
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
Medical Database
Biological Science Database (ProQuest)
Biotechnology and BioEngineering Abstracts
Environmental Science Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Environmental Science Collection
Genetics Abstracts
PubMed Central (Full Participant titles)
DOAJ: Directory of Open Access Journal (DOAJ)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Agricultural & Environmental Science Collection
Biological Science Collection
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
Toxicology Abstracts
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Environmental Science Database
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
Genetics Abstracts
DatabaseTitleList Publicly Available Content Database
MEDLINE

Genetics Abstracts

CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ (Directory of Open Access Journals)
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2072-6651
EndPage 1
ExternalDocumentID oai_doaj_org_article_e8b2598c3a24485d9dbfcfd8d5ed4b95
PMC4728523
3947663121
26703731
10_3390_toxins8010001
Genre Journal Article
GroupedDBID ---
53G
5VS
7X7
7XC
88E
8FE
8FH
8FI
8FJ
A8Z
AADQD
AAHBH
AAYXX
ABDBF
ABUWG
ACGFO
ACPRK
ACUHS
ADBBV
ADRAZ
AEGXH
AENEX
AEUYN
AFKRA
AFRAH
AFZYC
AIAGR
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CITATION
DIK
E3Z
EBD
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IPNFZ
KQ8
LK8
M1P
M48
M7P
MODMG
M~E
OK1
PATMY
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PYCSY
RIG
RNS
RPM
SV3
TR2
TUS
UKHRP
3V.
CGR
CUY
CVF
ECM
EIF
NPM
7T7
7U7
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
5PM
PUEGO
ID FETCH-LOGICAL-c514t-bae4cbc164619e5f4d7a088d1a9e5f1f1a8841e97264bfec123b9b2de11a2dc53
IEDL.DBID DOA
ISSN 2072-6651
IngestDate Wed Aug 27 01:31:17 EDT 2025
Thu Aug 21 18:23:49 EDT 2025
Mon Jul 21 11:00:26 EDT 2025
Fri Jul 25 09:57:11 EDT 2025
Wed Feb 19 02:00:20 EST 2025
Thu Apr 24 23:01:49 EDT 2025
Tue Jul 01 04:21:17 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords anthrax toxin
gene structure
gene transcription
ANTXR2
genetic polymorphism
Language English
License https://creativecommons.org/licenses/by/4.0
This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c514t-bae4cbc164619e5f4d7a088d1a9e5f1f1a8841e97264bfec123b9b2de11a2dc53
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-2293-5590
0000-0001-9376-2861
OpenAccessLink https://doaj.org/article/e8b2598c3a24485d9dbfcfd8d5ed4b95
PMID 26703731
PQID 1764191909
PQPubID 2032321
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_e8b2598c3a24485d9dbfcfd8d5ed4b95
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4728523
proquest_miscellaneous_1762367018
proquest_journals_1764191909
pubmed_primary_26703731
crossref_citationtrail_10_3390_toxins8010001
crossref_primary_10_3390_toxins8010001
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2015-12-22
PublicationDateYYYYMMDD 2015-12-22
PublicationDate_xml – month: 12
  year: 2015
  text: 2015-12-22
  day: 22
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Toxins
PublicationTitleAlternate Toxins (Basel)
PublicationYear 2015
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Reveille (ref_29) 2010; 42
Dahl (ref_39) 2008; 3
Gavrilov (ref_32) 2013; 41
Slater (ref_11) 2013; 110
Djebali (ref_22) 2012; 489
Koch (ref_20) 2007; 17
Miele (ref_31) 2009; 464
Bauer (ref_17) 2013; 342
Fulcher (ref_24) 2006; 61
Liu (ref_15) 2013; 5
Ha (ref_9) 2010; 285
Liu (ref_12) 2009; 106
Smemo (ref_18) 2014; 507
Deuquet (ref_28) 2012; 31
Zhang (ref_40) 2015; 1853
Martchenko (ref_16) 2012; 109
Loots (ref_23) 2004; 32
Young (ref_3) 2007; 76
Wei (ref_7) 2006; 124
Sastalla (ref_27) 2012; 80
Tamayo (ref_10) 2011; 81
Splinter (ref_33) 2004; 375
Tamayo (ref_8) 2008; 105
Turk (ref_1) 2007; 402
Guo (ref_30) 2012; 41
Mali (ref_34) 2013; 339
Liu (ref_14) 2013; 501
Heintzman (ref_21) 2007; 39
Liu (ref_2) 2014; 22
Dreszer (ref_19) 2012; 40
Kim (ref_37) 2014; 15
Liu (ref_13) 2010; 8
Lu (ref_6) 2004; 101
Fu (ref_36) 2014; 32
Scobie (ref_5) 2003; 100
Comer (ref_25) 2006; 41
Bradley (ref_4) 2001; 414
Ran (ref_35) 2013; 8
Sander (ref_38) 2014; 32
Larabee (ref_26) 2011; 79
16856939 - Mol Microbiol. 2006 Jul;61(2):324-37
18951182 - Methods Mol Biol. 2009;464:105-21
24684968 - Trends Microbiol. 2014 Jun;22(6):317-25
23995686 - Nature. 2013 Sep 5;501(7465):63-8
24690881 - Nat Rev Genet. 2014 May;15(5):321-34
24157548 - Nat Protoc. 2013 Nov;8(11):2281-308
17567990 - Genome Res. 2007 Jun;17(6):691-707
19858192 - J Biol Chem. 2010 Jan 15;285(3):2120-9
15215384 - Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W217-21
15569923 - Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17246-51
22118297 - Scand J Rheumatol. 2012 Feb;41(1):29-32
22215446 - EMBO J. 2012 Jan 4;31(1):3-13
16846716 - Microb Pathog. 2006 Aug-Sep;41(2-3):96-110
21576335 - Infect Immun. 2011 Aug;79(8):3302-8
12700348 - Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4
24115442 - Science. 2013 Oct 11;342(6155):253-7
25499265 - Biochim Biophys Acta. 2015 Feb;1853(2):481-8
23287722 - Science. 2013 Feb 15;339(6121):823-6
21075356 - Cell Host Microbe. 2010 Nov 18;8(5):455-62
21797942 - Mol Microbiol. 2011 Sep;81(5):1390-401
23716698 - Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7
20062062 - Nat Genet. 2010 Feb;42(2):123-7
17313374 - Biochem J. 2007 Mar 15;402(3):405-17
17277777 - Nat Genet. 2007 Mar;39(3):311-8
24646999 - Nature. 2014 Mar 20;507(7492):371-5
24584096 - Nat Biotechnol. 2014 Apr;32(4):347-55
23396278 - Nucleic Acids Res. 2013 Apr 1;41(6):3563-75
22315420 - Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2972-7
17335404 - Annu Rev Biochem. 2007;76:243-65
22086951 - Nucleic Acids Res. 2012 Jan;40(Database issue):D918-23
22104108 - Infect Immun. 2012 Feb;80(2):529-38
19617532 - Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
23271637 - Toxins (Basel). 2013 Jan;5(1):1-8
11700562 - Nature. 2001 Nov 8;414(6860):225-9
14870685 - Methods Enzymol. 2004;375:493-507
16564009 - Cell. 2006 Mar 24;124(6):1141-54
22955620 - Nature. 2012 Sep 6;489(7414):101-8
24463574 - Nat Biotechnol. 2014 Mar;32(3):279-84
18356299 - Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5254-9
18536650 - Nat Protoc. 2008;3(6):1032-45
References_xml – volume: 464
  start-page: 105
  year: 2009
  ident: ref_31
  article-title: Mapping Cis- and Trans- chromatin interaction networks using chromosome conformation capture (3C)
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-60327-461-6_7
– volume: 110
  start-page: 9932
  year: 2013
  ident: ref_11
  article-title: CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1302257110
– volume: 109
  start-page: 2972
  year: 2012
  ident: ref_16
  article-title: Human genetic variation altering anthrax toxin sensitivity
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1121006109
– volume: 80
  start-page: 529
  year: 2012
  ident: ref_27
  article-title: Anthrax edema toxin impairs clearance in mice
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.05947-11
– volume: 1853
  start-page: 481
  year: 2015
  ident: ref_40
  article-title: Involvement of aberrant miR-139/Jun feedback loop in human gastric cancer
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2014.12.002
– volume: 41
  start-page: 3563
  year: 2013
  ident: ref_32
  article-title: Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub
  publication-title: Nucl. Acids Res.
  doi: 10.1093/nar/gkt067
– volume: 41
  start-page: 96
  year: 2006
  ident: ref_25
  article-title: Murine macrophage transcriptional and functional responses to bacillus anthracis edema toxin
  publication-title: Microb. Pathog.
  doi: 10.1016/j.micpath.2006.05.001
– volume: 106
  start-page: 12424
  year: 2009
  ident: ref_12
  article-title: Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0905409106
– volume: 39
  start-page: 311
  year: 2007
  ident: ref_21
  article-title: Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
  publication-title: Nat. Genet.
  doi: 10.1038/ng1966
– volume: 501
  start-page: 63
  year: 2013
  ident: ref_14
  article-title: Key tissue targets responsible for anthrax-toxin-induced lethality
  publication-title: Nature
  doi: 10.1038/nature12510
– volume: 101
  start-page: 17246
  year: 2004
  ident: ref_6
  article-title: Est-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0407794101
– volume: 105
  start-page: 5254
  year: 2008
  ident: ref_8
  article-title: COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0710100105
– volume: 42
  start-page: 123
  year: 2010
  ident: ref_29
  article-title: Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
  publication-title: Nat. Genet.
  doi: 10.1038/ng.513
– volume: 76
  start-page: 243
  year: 2007
  ident: ref_3
  article-title: Anthrax toxin: Receptor binding, internalization, pore formation, and translocation
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.75.103004.142728
– volume: 81
  start-page: 1390
  year: 2011
  ident: ref_10
  article-title: GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.2011.07770.x
– volume: 342
  start-page: 253
  year: 2013
  ident: ref_17
  article-title: An erythroid enhancer of bcl11a subject to genetic variation determines fetal hemoglobin level
  publication-title: Science
  doi: 10.1126/science.1242088
– volume: 61
  start-page: 324
  year: 2006
  ident: ref_24
  article-title: Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.2006.05232.x
– volume: 5
  start-page: 1
  year: 2013
  ident: ref_15
  article-title: The receptors that mediate the direct lethality of anthrax toxin
  publication-title: Toxins
  doi: 10.3390/toxins5010001
– volume: 339
  start-page: 823
  year: 2013
  ident: ref_34
  article-title: RNA-guided human genome engineering via cas9
  publication-title: Science
  doi: 10.1126/science.1232033
– volume: 124
  start-page: 1141
  year: 2006
  ident: ref_7
  article-title: The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin
  publication-title: Cell
  doi: 10.1016/j.cell.2005.12.045
– volume: 402
  start-page: 405
  year: 2007
  ident: ref_1
  article-title: Manipulation of host signalling pathways by anthrax toxins
  publication-title: Biochem. J.
  doi: 10.1042/BJ20061891
– volume: 22
  start-page: 317
  year: 2014
  ident: ref_2
  article-title: Anthrax lethal and edema toxins in anthrax pathogenesis
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2014.02.012
– volume: 3
  start-page: 1032
  year: 2008
  ident: ref_39
  article-title: A rapid micro chromatin immunoprecipitation assay (microChIP)
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.68
– volume: 100
  start-page: 5170
  year: 2003
  ident: ref_5
  article-title: Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0431098100
– volume: 31
  start-page: 3
  year: 2012
  ident: ref_28
  article-title: The dark sides of capillary morphogenesis gene 2
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.442
– volume: 41
  start-page: 29
  year: 2012
  ident: ref_30
  article-title: Association of the ANTXR2 gene polymorphism and ankylosing spondylitis in Chinese Han
  publication-title: Scand. J. Rheumatol.
  doi: 10.3109/03009742.2011.600700
– volume: 32
  start-page: 279
  year: 2014
  ident: ref_36
  article-title: Improving CRISPR-Cas nuclease specificity using truncated guide rnas
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2808
– volume: 32
  start-page: 347
  year: 2014
  ident: ref_38
  article-title: CRISPR-Cas systems for editing, regulating and targeting genomes
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2842
– volume: 414
  start-page: 225
  year: 2001
  ident: ref_4
  article-title: Identification of the cellular receptor for anthrax toxin
  publication-title: Nature
  doi: 10.1038/n35101999
– volume: 79
  start-page: 3302
  year: 2011
  ident: ref_26
  article-title: Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.05070-11
– volume: 507
  start-page: 371
  year: 2014
  ident: ref_18
  article-title: Obesity-associated variants within FTO form long-range functional connections with IRX3
  publication-title: Nature
  doi: 10.1038/nature13138
– volume: 17
  start-page: 691
  year: 2007
  ident: ref_20
  article-title: The landscape of histone modifications across 1% of the human genome in five human cell lines
  publication-title: Genome Res.
  doi: 10.1101/gr.5704207
– volume: 8
  start-page: 455
  year: 2010
  ident: ref_13
  article-title: Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of bacillus anthracis infections in mice
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2010.10.004
– volume: 32
  start-page: W217
  year: 2004
  ident: ref_23
  article-title: Rvista 2.0: Evolutionary analysis of transcription factor binding sites
  publication-title: Nucl. Acids Res.
  doi: 10.1093/nar/gkh383
– volume: 8
  start-page: 2281
  year: 2013
  ident: ref_35
  article-title: Genome engineering using the CRISPR-Cas9 system
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.143
– volume: 40
  start-page: D918
  year: 2012
  ident: ref_19
  article-title: The UCSC genome browser database: Extensions and updates 2011
  publication-title: Nucl. Acids Res.
  doi: 10.1093/nar/gkr1055
– volume: 285
  start-page: 2120
  year: 2010
  ident: ref_9
  article-title: Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.065813
– volume: 489
  start-page: 101
  year: 2012
  ident: ref_22
  article-title: Landscape of transcription in human cells
  publication-title: Nature
  doi: 10.1038/nature11233
– volume: 15
  start-page: 321
  year: 2014
  ident: ref_37
  article-title: A guide to genome engineering with programmable nucleases
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3686
– volume: 375
  start-page: 493
  year: 2004
  ident: ref_33
  article-title: 3C technology: Analyzing the spatial organization of genomic loci in vivo
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(03)75030-7
– reference: 21797942 - Mol Microbiol. 2011 Sep;81(5):1390-401
– reference: 15569923 - Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17246-51
– reference: 16856939 - Mol Microbiol. 2006 Jul;61(2):324-37
– reference: 24646999 - Nature. 2014 Mar 20;507(7492):371-5
– reference: 21075356 - Cell Host Microbe. 2010 Nov 18;8(5):455-62
– reference: 19858192 - J Biol Chem. 2010 Jan 15;285(3):2120-9
– reference: 22315420 - Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2972-7
– reference: 18951182 - Methods Mol Biol. 2009;464:105-21
– reference: 17567990 - Genome Res. 2007 Jun;17(6):691-707
– reference: 17313374 - Biochem J. 2007 Mar 15;402(3):405-17
– reference: 24584096 - Nat Biotechnol. 2014 Apr;32(4):347-55
– reference: 20062062 - Nat Genet. 2010 Feb;42(2):123-7
– reference: 24115442 - Science. 2013 Oct 11;342(6155):253-7
– reference: 22118297 - Scand J Rheumatol. 2012 Feb;41(1):29-32
– reference: 14870685 - Methods Enzymol. 2004;375:493-507
– reference: 17335404 - Annu Rev Biochem. 2007;76:243-65
– reference: 23716698 - Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7
– reference: 23995686 - Nature. 2013 Sep 5;501(7465):63-8
– reference: 23287722 - Science. 2013 Feb 15;339(6121):823-6
– reference: 22955620 - Nature. 2012 Sep 6;489(7414):101-8
– reference: 23396278 - Nucleic Acids Res. 2013 Apr 1;41(6):3563-75
– reference: 18356299 - Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5254-9
– reference: 24463574 - Nat Biotechnol. 2014 Mar;32(3):279-84
– reference: 24684968 - Trends Microbiol. 2014 Jun;22(6):317-25
– reference: 16564009 - Cell. 2006 Mar 24;124(6):1141-54
– reference: 22215446 - EMBO J. 2012 Jan 4;31(1):3-13
– reference: 12700348 - Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4
– reference: 25499265 - Biochim Biophys Acta. 2015 Feb;1853(2):481-8
– reference: 21576335 - Infect Immun. 2011 Aug;79(8):3302-8
– reference: 15215384 - Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W217-21
– reference: 19617532 - Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
– reference: 24157548 - Nat Protoc. 2013 Nov;8(11):2281-308
– reference: 23271637 - Toxins (Basel). 2013 Jan;5(1):1-8
– reference: 22104108 - Infect Immun. 2012 Feb;80(2):529-38
– reference: 16846716 - Microb Pathog. 2006 Aug-Sep;41(2-3):96-110
– reference: 22086951 - Nucleic Acids Res. 2012 Jan;40(Database issue):D918-23
– reference: 17277777 - Nat Genet. 2007 Mar;39(3):311-8
– reference: 18536650 - Nat Protoc. 2008;3(6):1032-45
– reference: 24690881 - Nat Rev Genet. 2014 May;15(5):321-34
– reference: 11700562 - Nature. 2001 Nov 8;414(6860):225-9
SSID ssj0000331917
Score 2.0617957
Snippet Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility....
Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility....
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1
SubjectTerms anthrax toxin
Antigens, Bacterial - toxicity
ANTXR2
Bacterial Toxins - toxicity
Cell Line
Communication
Enhancer Elements, Genetic
Gene mapping
gene structure
gene transcription
Genetic diversity
genetic polymorphism
Genetic Predisposition to Disease
Genetic Variation
HEK293 Cells
Humans
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Receptors, Peptide - genetics
Toxins
SummonAdditionalLinks – databaseName: Health & Medical Collection (ProQuest)
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwELYKXHpBLfSxLSAjVZwasXac2OZSLQiEKoFQC9LeIr8CK4FDya60_HvGXm_aIOgxthVNxvb4m_HkG4S-SUFrxUSdMcnKjDlrMsW1yYaOG60BcJs6_OB8dl6eXrGf42KcAm5tSqtc2sRoqG1jQox8n_CSgW8hh_LH_Z8sVI0Kt6uphMYKWgvUZSGli495F2MZ5nlwRxbUmjl49_vTZj7xLVjlgG16R1Fk7H8JZj7Plvzn-Dl5h9YTbsSjxUS_R2-c30CbIw8-890j3sMxkzOGyDfRRax-oOb496yNWSsxAfbxAMeIPQ5M0_AWfNHcguMPep60dy0-a2ys5OWv8ej8cvyL4uN5SpL1H9DVyfHl0WmWKidkBgDQNNPKMaNN4A4j0hU1s1yBObFEhSdSEyUEI05ygEO6dgaOLy01tY4QRa0p8o9o1TfefUZ4qJVlFmCS1SVzjiqqRGkBhIjC5qwQA_R9qcTKJFrxUN3itgL3Iui86ul8gPa64fcLPo3XBh6GGekGBRrs2NA8XFdpV1VOaHDfhMkVoBQQSFpdm9oKWzjLtCwGaGs5n1Xam231dyUN0G7XDbsqXJUo75pZHBOp7Qh836fF9HeSUGjPeQ4S8t7C6Ina7_GTm8jczTgV4Pl_-b9YX9FbgGVFSJqhdAutTh9mbhugz1TvxPX9BFiACJQ
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdgvPCCYOOjMCYjoT0RqB07tpHQ1KFNE1KnCVapb5G_slVqHWhaqf3vObtpITDeeIxziew7n_075_I7hN4qSSvNZJUxxYqMeWczLYzN-l5YYwBw2yr-4Dy8LC5G7MuYj39RCrUKbO4M7WI9qdF8-n71Y30CDv8pRpwQsn9Y1KtJaGCpjYDlPnoAm5KIPjpskX5alPM8RiYbls2_n-rsSom8_y7E-Wfi5G870flj9KiFkHiwsfkTdM-HfXQwCBA-z9b4GKekznRafoCuUiEEvcLflk1KYEm5sOuPOB3e40g6DW_BV_V0PatB5ZNm1uBh7VJRr3CDB5fX468Un63afNnwFI3Oz64_X2RtEYXMAhZaZEZ7Zo2NNGJEeV4xJzSsLI7oeEUqoqVkxCsByMhU3sJOZpShzhOiqbM8f4b2Qh38C4T7RjvmADE5UzDvqaZaFg7wiOQuZ1z20LutEkvbMozHQhfTEiKNqPOyo_MeOt6Jf99Qa_xL8DRaZCcUGbFTQz2_KVsHK700EMlJm2sALNAh5UxlKycd944ZxXvocGvPcjvLSiIKBtNC9VUPvdndBgeLX0108PUyySSWOwLje74x_64nFNpzkUMPRWdidLravRMmt4nEmwkqOc1f_o-xvUIPAcfxmGVD6SHaW8yX_jVgpYU5Sl7wE9tzGZg
  priority: 102
  providerName: Scholars Portal
Title Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression
URI https://www.ncbi.nlm.nih.gov/pubmed/26703731
https://www.proquest.com/docview/1764191909
https://www.proquest.com/docview/1762367018
https://pubmed.ncbi.nlm.nih.gov/PMC4728523
https://doaj.org/article/e8b2598c3a24485d9dbfcfd8d5ed4b95
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9swEBdr97KX0q-t6bqgwejTTCNZtqS-pSOlDBJCPyBvRl9uA6085gTS_34n2Q3xWOnLXgy2DiOdTrrfyeffIfRNCloqJsqESZYnzFmTKK5NMnDcaA2A25ThB-fxJL-6Yz9n2Wyj1FfICWvogRvFnTmhAaELkypwRCKz0urSlFbYzFmmZWQvBZ-3EUzFPThNQyDSkGqmENefLarV3NewHwdU03FCkav_XwDz7zzJDcdzuYt2WsSIh01P99A75_fRwdBDtPz0jE9xzOGMh-MHaBrrHqgVvlnWMV8lpr4-n-N4Vo8DxzS8BU-rRwj5QcPz-qnG48rGGl7-Hg8nt7NrikerNj3WH6K7y9Htj6ukrZmQGIA-i0Qrx4w2gTWMSJeVzHIFG4klKtyRkighGHGSAxDSpTPguLTU1DpCFLUmSz-ibV95d4TwQCvLLAAkq3PmHFVUidwC_IBZSFkmeuj7ixIL0xKKh7oWjwUEFkHnRUfnPXS6Fv_VMGm8JngRZmQtFAiw4wMwi6I1i-Its-ihk5f5LNpVWReE5wzMQg5kD31dN8N6Ch9JlHfVMspEUjsC4_vUTP-6JxSepzyFHvKOYXS62m3x84fI2c04FRDzH_-PsX1GHwC2ZSGphtITtL34vXRfABotdB9t8Rnvo_cXo8n0uh_XBFzHTPwBRV8VyA
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELem7gFeEDA-ygYYCfZEtMZ2EgcJoQ46dWytqtFJfQv-yqi0JtvSivaf4m_k7HxAEPC2xzin6HJ3Pv_OPt8h9DrmJBWMpx6LWegxo5UnIqm8nomUlAC4VWovOI_G4fCcfZ4Fsy30o74LY9Mqa5_oHLXOld0jP_CjkEFsEffiD1fXnu0aZU9X6xYapVmcmM13CNmK98efQL9vCDkaTD8OvaqrgKcAHCw9KQxTUtm6Wn5sgpTpSMBU076wT37qC86Zb-IIoIJMjQLXLmNJtPF9QbSyXSLA5W8zCqFMB20fDsaTs2ZXp0epDYDKYp6Uxr2DZb6eZwWsAxZNtRY_1yPgb8D2z_zM3xa8o_voXoVUcb80rQdoy2QP0U4_gyh9scH72OWOuk35HTRx_RbEGn9ZFS5PxqXcbt5hd0aAbW1r-Aqe5JebRQ6anReLAo9y7XqHZRe4P57OzggerKu03OwROr8VqT5GnSzPzFOEe1JopgGYaRkyY4gggocaYA8PNGUB76K3tRATVRUyt_00LhMIaKzMk5bMu2i_Ib8qK3j8i_DQaqQhsoW33UB-c5FU8zgxXELAyBUVgIuAoVjLVKWa68BoJuOgi_ZqfSaVNyiSX7bbRa-a1zCP7eGMyEy-cjSumJ4P__ekVH_DCYFxGlHgMGoZRovV9pts_s3VCmcR4QGhz_7P1kt0ZzgdnSanx-OTXXQXQGFgU3YI2UOd5c3KPAfgtZQvKmvH6OttT7Cf69lIAw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLamISFeEGNcCgOMBHsiamM7sYOEUGGrNsaqCjapb5lvGZXWZFta0f41fh3HzgWCgLc9xrGik3Pzd-zjcxB6lQiSSSaygCUsDpg1OpBc6WBguVYKALfO3AXn43F8cMo-TaPpBvrR3IVxaZWNT_SO2hTa7ZH3Qx4ziC2SQdLP6rSIyd7o_eVV4DpIuZPWpp1GpSJHdv0dwrfy3eEeyPo1IaP9k48HQd1hINAAFBaBkpZppV2NrTCxUcYMl2B2JpTuKcxCKQQLbcIBNqjManDzKlHE2DCUxGjXMQLc_y1Oo9DZGJ_ydn9nQKkLhaqynpQmg_6iWM3yElYEh6s6y6DvFvA3iPtnpuZvS9_oHrpbY1Y8rJRsC23Y_D7aHuYQr8_XeBf7LFK_Pb-NJr7zglzhr8vSZ8z45Nv1W-xPC7Crcg1fwZPiYj0vQMazcl7i48L4LmL5OR6OT6ZfCN5f1Qm6-QN0eiM8fYg28yK3jxEeKGmYAYhmVMysJZJIERsAQCIylEWih940TEx1XdLcdda4SCG0cTxPOzzvod12-mVVy-NfEz84ibSTXAluP1Bcn6e1RadWKAgdhaYSEBIQlBiV6cwIE1nDVBL10E4jz7T2C2X6S4t76GX7GizaHdPI3BZLP8eX1Qvh_x5V4m8pITBOOQUKeUcxOqR23-Szb75qOONERIQ--T9ZL9BtMKv08-H46Cm6A-gwcrk7hOygzcX10j4DBLZQz72qY3R207b1E0AdStM
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Anthrax+Susceptibility%3A+Human+Genetic+Polymorphisms+Modulating+ANTXR2+Expression&rft.jtitle=Toxins&rft.au=Zhang+Zhang&rft.au=Yan+Zhang&rft.au=Minglei+Shi&rft.au=Bingyu+Ye&rft.date=2015-12-22&rft.pub=MDPI+AG&rft.eissn=2072-6651&rft.volume=8&rft.issue=1&rft.spage=1&rft_id=info:doi/10.3390%2Ftoxins8010001&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_e8b2598c3a24485d9dbfcfd8d5ed4b95
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2072-6651&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2072-6651&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2072-6651&client=summon