Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial

• Published in: International journal of dentistry Vol. 2021; pp. 8840167 - 9
• Main Authors: Ahmed, Enji, Shaker, Olfat G., Yussif, Nermin, Ghalwash, Dalia M.
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 2021; Hindawi Limited; Wiley
• Subjects: Antioxidants; Bone resorption; Cellulose; Clinical trials; Dentistry; Enzyme-linked immunosorbent assay; Gelatinase B; Gum disease; Immunomodulation; Inflammation; Matrix metalloproteinase; Melatonin; Metalloproteinase; Oral hygiene; Oxidative stress; Patients; Periodontics; Periodontitis; Pharmacy; Placebos; Reactive oxygen species; Statistical analysis

Objectives. Periodontitis is characterized by inflammatory destruction of periodontal tissue, loss of attachment, and bone resorption. The increase in reactive oxygen species (ROS) is responsible for the oxidative damage occurring in periodontal tissues. Melatonin has important immunomodulatory, ant...