Airway Surfactant Protein D Deficiency in Adults With Severe Asthma

• Published in: Chest Vol. 149; no. 5; p. 1165
• Main Authors: Mackay, Rose-Marie A, Grainge, Christopher L, Lau, Laurie C, Barber, Clair, Clark, Howard W, Howarth, Peter H
• Format: Journal Article
• Language: English
• Published: United States 01.05.2016
• Subjects: Adolescent; Adult; Aged; Asthma - immunology; Asthma - metabolism; Blotting, Western; Bronchoalveolar Lavage Fluid - chemistry; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Eosinophil Cationic Protein - metabolism; Female; Humans; Immunity, Innate - immunology; Leukocyte Count; Leukocyte Elastase - metabolism; Lipopolysaccharides - metabolism; Male; Middle Aged; Neutrophils; Peroxidase - metabolism; Pulmonary Surfactant-Associated Protein D - immunology; Pulmonary Surfactant-Associated Protein D - metabolism; Severity of Illness Index; Young Adult; biomarkers; severe asthma; neutrophilic inflammation; asthma; eosinophilic inflammation; bronchoalveolar lavage; immunology (lung); surfactant protein D; immunology asthma

Surfactant protein D (SP-D) is an essential component of the innate immune defense against pathogens within the airways. SP-D also regulates allergic inflammation and promotes the removal of apoptotic cells. SP-D dysregulation is evident in several pulmonary diseases. Our aim was to investigate whet...