Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder

• Published in: The international journal of neuropsychopharmacology Vol. 16; no. 7; pp. 1505 - 1512
• Main Authors: Soeiro-de-Souza, Márcio Gerhardt, Andreazza, Ana C., Carvalho, Andre F., Machado-Vieira, Rodrigo, Young, L. Trevor, Moreno, Ricardo Alberto
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2013; Oxford University Press
• Subjects: 5-Methylcytosine - analogs & derivatives; Adolescent; Adult; Bipolar disorder; Bipolar Disorder - metabolism; Bipolar Disorder - physiopathology; Cytosine - analogs & derivatives; Cytosine - metabolism; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; DNA - metabolism; DNA methylation; DNA Methylation - physiology; Enzyme-Linked Immunosorbent Assay; Female; Health care; Humans; Male; Multivariate Analysis; Oxidation-Reduction; Oxidative Stress - physiology; Young Adult; 5-hydroxymethylcystosine; Bipolar disorder; 5-methylcytosine; oxidative stress; 8-hydroxy-2-deoxyguanosine

Bipolar disorder (BD) is a major public health problem characterized by progressive functional impairment. A number of clinical variables have been associated with progression of the disease, most notably number of affective episodes and presence of psychotic symptoms, both of which correlate with g...