Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier

• Published in: Frontiers in Drug Delivery Vol. 3
• Main Author: Pardridge, William M.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 10.07.2023
• Subjects: Alzheimer’s disease; insulin receptor; monoclonal antibody; Parkinson’s disease; receptor-mediated transcytosis; transferrin receptor

Therapeutic antibody drug development is a rapidly growing sector of the pharmaceutical industry. However, antibody drug development for the brain is a technical challenge, and therapeutic antibodies for the central nervous system account for ∼3% of all such agents. The principal obstacle to antibod...