Helicobacter pylori-Specific CD4⁺ T Cells Home to and Accumulate in the Human Helicobacter pylori-Infected Gastric Mucosa

• Published in: Infection and Immunity Vol. 73; no. 9; pp. 5612 - 5619
• Main Authors: Lundgren, Anna, Trollmo, Christina, Edebo, Anders, Svennerholm, Ann-Mari, Lundin, B. Samuel
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.2005
• Subjects: Adult; antigens; bacteria; Bacteriology; Biological and medical sciences; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - microbiology; Cell Aggregation - immunology; cell culture; Cell Movement - immunology; chemokines; Chemokines - biosynthesis; cross reaction; duodenum; Female; Fundamental and applied biological sciences. Psychology; gastric mucosa; Gastric Mucosa - immunology; Gastric Mucosa - microbiology; Helicobacter Infections - immunology; Helicobacter pylori; Helicobacter pylori - immunology; Host Response and Inflammation; Humans; interleukin-2; interleukin-7; Male; Microbiology; Middle Aged; Miscellaneous; receptors; Receptors, CCR3; Receptors, CCR5 - biosynthesis; Receptors, Chemokine - biosynthesis; Receptors, Lymphocyte Homing - biosynthesis; T-lymphocytes; Human; Infection; Spirillales; Helicobacter pylori; Microbiology; Mucosa; T-Lymphocyte; Spirillaceae; Bacteria; Immunity

Helicobacter pylori infects the stomach and duodenal mucosa. T cells are important components of the H. pylori-induced immune response, but little is currently known about how these cells are recruited to the infected mucosa. Here, we have characterized stomach and duodenal T cells isolated from H....