Clonal expansions in ulcerative colitis identify patients with neoplasia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 49; pp. 20871 - 20876
• Main Authors: Salk, Jesse J, Salipante, Stephen J, Risques, Rosa Ana, Crispin, David A, Li, Lin, Bronner, Mary P, Brentnall, Teresa A, Rabinovitch, Peter S, Horwitz, Marshall S, Loeb, Lawrence A
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 08.12.2009; National Acad Sciences
• Subjects: Alleles; Biological Sciences; Biopsies; Biopsy; Cancer; Carcinogenesis; Cell lines; Cell Proliferation; Clone Cells; clones; Cloning; colitis; Colitis, Ulcerative - pathology; colon; Colonic Neoplasms - diagnosis; Colonic Neoplasms - pathology; colorectal neoplasms; Electrophoresis, Agar Gel; evolution; Genetic mutation; Genotype; Genotypes; Guanine - metabolism; Histology; Humans; inflammation; Inflammatory bowel disease; Models, Biological; mutants; Mutation; Mutation - genetics; patients; risk; Risk factors; Stem cells; Tissues; Tumors; Ulcerative colitis

Chronic inflammation predisposes to a variety of human cancers. Affected tissues slowly accumulate mutations, some of which affect growth regulation and drive successive waves of clonal evolution, whereas a far greater number are functionally neutral and serve only to passively mark expanding clones...