A Pharmacokinetic and Pharmacodynamic Study of Oral Oxycodone in a Human Experimental Pain Model of Hyperalgesia

• Published in: Clinical pharmacokinetics Vol. 49; no. 12; pp. 817 - 827
• Main Authors: Olesen, Anne E., Upton, Richard, Foster, David J. R., Staahl, Camilla, Christrup, Lona L., Arendt-Nielsen, Lars, Drewes, Asbjørn M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2010; Adis International; Wolters Kluwer Health, Inc; Springer Nature B.V
• Subjects: Acids; Administration, Oral; Adult; Analgesics, Opioid - pharmacokinetics; Analgesics, Opioid - pharmacology; Biological and medical sciences; Capsaicin; Complications and side effects; Cross-Over Studies; Dosage and administration; Double-Blind Method; Esophagus - pathology; Female; General pharmacology; Humans; Hyperalgesia - drug therapy; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Original Research Article; Oxycodone; Oxycodone - pharmacokinetics; Oxycodone - pharmacology; Pain Measurement; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Time Factors; Young Adult; Denmark; Pain Measure; Capsaicin; Opioid Receptor; Oxycodone; Oxymorphone; Human; Pharmacokinetic pharmacodynamic relationship; Nervous system diseases; Pain; Oral administration; Opiates; Models; Narcotic analgesic; Hyperalgesia

Background and Objective Oxycodone is not as well characterized, with respect to its pharmacokinetic/ pharmacodynamic properties, as other opioids. Moreover, the pharmacodynamic profile of oxycodone can be affected by changes in the pain system, e.g. hyperalgesia. Therefore, the aim of this study wa...