A Pharmacokinetic and Pharmacodynamic Study of Oral Oxycodone in a Human Experimental Pain Model of Hyperalgesia - Olesen, Anne E.; Upton, Richard; Foster, David J. R.; Staahl, Camilla; Christrup, Lona L.; Arendt-Nielsen, Lars; Drewes, Asbjørn M. (Clinical pharmacokinetics, 2010)
Keywords: Acids; Administration, Oral; Adult; Analgesics, Opioid - pharmacokinetics; Analgesics, Opioid - pharmacology; Biological and medical sciences; Capsaicin; Complications and side effects; Cross-Over Studies; Dosage and administration; Double-Blind Method; Esophagus - pathology; Female; General pharmacology; Humans; Hyperalgesia - drug therapy; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Original Research Article; Oxycodone; Oxycodone - pharmacokinetics; Oxycodone - pharmacology; Pain Measurement; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Time Factors; Young Adult; Denmark; Pain Measure; Capsaicin; Opioid Receptor; Oxycodone; Oxymorphone; Human; Pharmacokinetic pharmacodynamic relationship; Nervous system diseases; Pain; Oral administration; Opiates; Models; Narcotic analgesic; Hyperalgesia