Local palmitoylation cycles define activity-regulated postsynaptic subdomains

• Published in: The Journal of cell biology Vol. 202; no. 1; pp. 145 - 161
• Main Authors: Fukata, Yuko, Dimitrov, Ariane, Boncompain, Gaelle, Vielemeyer, Ole, Perez, Franck, Fukata, Masaki
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 08.07.2013; The Rockefeller University Press
• Subjects: Animals; Cells; Cercopithecus aethiops; COS Cells; Dendritic Spines - drug effects; Dendritic Spines - metabolism; Disks Large Homolog 4 Protein; Fluorescent Dyes - metabolism; Green Fluorescent Proteins - metabolism; Guanylate Kinases - metabolism; HEK293 Cells; Hippocampus - metabolism; Humans; Lipoylation; Membrane Proteins - metabolism; Membranes; Mice; Neuronal Plasticity; Neurons - metabolism; Palmitates - pharmacology; Plasma; Post-Synaptic Density - metabolism; Rats; Sensitivity and Specificity; Structure-Activity Relationship; Synaptic Transmission; Transfection

Distinct PSD-95 clusters are primary landmarks of postsynaptic densities (PSDs), which are specialized membrane regions for synapses. However, the mechanism that defines the locations of PSD-95 clusters and whether or how they are reorganized inside individual dendritic spines remains controversial....