Cactus Pear Extracts Induce Reactive Oxygen Species Production and Apoptosis in Ovarian Cancer Cells

• Published in: Nutrition and cancer Vol. 62; no. 5; pp. 692 - 699
• Main Authors: Feugang, Jean M, Ye, Fei, Zhang, David Y, Yu, Yanhong, Zhong, Mei, Zhang, Sui, Zou, Changping
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.01.2010; Taylor& Francis; Taylor & Francis Ltd
• Subjects: analysis; antagonists & inhibitors; antineoplastic agents; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Cactaceae; Cactus; cell growth; Cells; DNA fragmentation; drug effects; drug therapy; Feeding. Feeding behavior; Female; Female genital diseases; Fruit; Fundamental and applied biological sciences. Psychology; gene expression; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Neoplastic - drug effects; Genes; Gynecology; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; metabolism; Neoplasm Proteins; Neoplasm Proteins - analysis; NF-kappa B; NF-kappa B - antagonists & inhibitors; Opuntia; Ovarian cancer; ovarian neoplasms; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; ovaries; Oxygen; pathology; pharmacology; plant extracts; Plant Extracts - pharmacology; reactive oxygen species; Reactive Oxygen Species - metabolism; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Ovarian diseases; Oxygen; Cancerology; Ovary cancer; Production; Extract; Malignant tumor; Species; Tumor cell; Cancer; Female genital diseases; Apoptosis

The protective effect of natural products such as fruits and vegetables against cancer has attracted great attention because of their fewer side effects and therefore, potentially greater safety. We have previously reported that cactus pear mixture aqueous extract (CME) reduces gynecologic cancer ce...