Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats

• Published in: International journal of molecular sciences Vol. 16; no. 9; pp. 20595 - 20608
• Main Authors: Wang, Peng, Huang, Jian, Li, Yi, Chang, Ruiming, Wu, Haidong, Lin, Jiali, Huang, Zitong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.08.2015; MDPI
• Subjects: Acute Kidney Injury - etiology; Acute Kidney Injury - metabolism; Acute Kidney Injury - mortality; Acute Kidney Injury - pathology; Acute Kidney Injury - therapy; Animals; Apoptosis; Blood Urea Nitrogen; Carbon monoxide; Carbon Monoxide - administration & dosage; Carrier Proteins - metabolism; Creatinine - blood; Cytokines - blood; Cytokines - metabolism; Disease Models, Animal; Inflammasomes - metabolism; Inflammation Mediators - blood; Inflammation Mediators - metabolism; Inflammatory diseases; Kidney diseases; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Rodents; Sepsis; Sepsis - complications; carbon monoxide; acute kidney injury; NLRP3 inflammasome; sepsis

Carbon monoxide (CO) has shown various physiological effects including anti-inflammatory activity in several diseases, whereas the therapeutic efficacy of CO on sepsis-induced acute kidney injury (AKI) has not been reported as of yet. The purpose of the present study was to explore the effects of ex...