Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

• Published in: Journal of allergy and clinical immunology Vol. 138; no. 2; pp. 336 - 349
• Main Authors: Werfel, Thomas, Allam, Jean-Pierre, Biedermann, Tilo, Eyerich, Kilian, Gilles, Stefanie, Guttman-Yassky, Emma, Hoetzenecker, Wolfram, Knol, Edward, Simon, Hans-Uwe, Wollenberg, Andreas, Bieber, Thomas, Lauener, Roger, Schmid-Grendelmeier, Peter, Traidl-Hoffmann, Claudia, Akdis, Cezmi A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016; Elsevier Limited
• Subjects: adaptive; Age Factors; Allergens - immunology; Allergies; Allergy and Immunology; Antigens; Asthma; Atopic dermatitis; Bacteria; Carrier Proteins - metabolism; Cytokines; Dendritic cells; Dermatitis; Dermatitis, Atopic - diagnosis; Dermatitis, Atopic - etiology; Dermatitis, Atopic - metabolism; Dermatitis, Atopic - therapy; Disease; Eczema; Environmental Exposure; filaggrin; Gram-positive bacteria; Granulocytes; Human subjects; Humans; IgE; IL-13; IL-31; IL-4; Immune System - cytology; Immune System - immunology; Immune System - metabolism; Immunity, Cellular; Immunity, Humoral; Immunity, Innate; Immunoglobulin E - immunology; Inflammation; innate; Intermediate Filament Proteins - metabolism; Ligands; Lymphocytes; Microbiota - immunology; Organic chemicals; Pollutants; Protein Binding; Proteins; Pruritus - immunology; Pruritus - metabolism; Psoriasis - diagnosis; Psoriasis - etiology; Psoriasis - metabolism; skin; skin barrier; Skin diseases; TH2; Viral infections; FLG; skin barrier; AD; AMP; TSLP; IgE; innate; IL-4; skin; IL-13; IL-31; HDM; ILC2; adaptive; TRP; Atopic dermatitis; CNF; filaggrin; TH2; DC; T H2; Cutaneous nerve fiber; Dendritic cell; House dust mite; Transient receptor potential; Thymic stromal lymphopoietin; Type 2 innate lymphoid cell; Antimicrobial peptide; T(H)2

Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of the atopic diathesis. Recent evidence supports the concept that AD can also recognize other comorbidities, such as chronic inflammatory bowel or cardiovascular diseases. These comorbidities might result fro...