Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on t...

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Published inGenes Vol. 11; no. 5; p. 556
Main Authors Milazzo, Giorgio, Mercatelli, Daniele, Di Muzio, Giulia, Triboli, Luca, De Rosa, Piergiuseppe, Perini, Giovanni, Giorgi, Federico M.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 15.05.2020
MDPI
Subjects
antineoplastic agents
Antineoplastic Agents - therapeutic use
Arthropods
Cell cycle
Chelonia mydas
chromatin
Chromatin remodeling
Enzymes
Eukaryotes
Evolutionary conservation
Gene expression
Genomes
HDAC protein
Histone deacetylase
Histone Deacetylase Inhibitors - therapeutic use
Histone Deacetylases - genetics
Histones
Histones - genetics
Humans
Insects
Mammals
moieties
Nematodes
Neoplasms - genetics
Neoplasms - therapy
Organisms
Pathogenesis
Phylogenetics
Proteins
Reptiles & amphibians
Review
Substrate Specificity - genetics
tissues
Transcription
transcription (genetics)
Transcription Factors - genetics
Yeast
Zebrafish
gene networks
phylogenesis
epigenomics
histone deacetylases
HDAC inhibitors
cancer
chromatin
HDACi
epigenetics
HDAC
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Abstract Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.
AbstractList Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.
Author Milazzo, Giorgio
Mercatelli, Daniele
Perini, Giovanni
Di Muzio, Giulia
Giorgi, Federico M.
Triboli, Luca
De Rosa, Piergiuseppe
AuthorAffiliation Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi 3, 41026 Bologna, Italy; giorgio.milazzo@unibo.it (G.M.); danielemercatelli@gmail.com (D.M.); giulia.dimuzio@studio.unibo.it (G.D.M.); luca.triboli@studenti.unitn.it (L.T.); piergiuseppe.derosa2@unibo.it (P.D.R.); giovanni.perini@unibo.it (G.P.)
AuthorAffiliation_xml – name: Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi 3, 41026 Bologna, Italy; giorgio.milazzo@unibo.it (G.M.); danielemercatelli@gmail.com (D.M.); giulia.dimuzio@studio.unibo.it (G.D.M.); luca.triboli@studenti.unitn.it (L.T.); piergiuseppe.derosa2@unibo.it (P.D.R.); giovanni.perini@unibo.it (G.P.)
Author_xml – sequence: 1
  givenname: Giorgio
  surname: Milazzo
  fullname: Milazzo, Giorgio
– sequence: 2
  givenname: Daniele
  orcidid: 0000-0003-3228-0580
  surname: Mercatelli
  fullname: Mercatelli, Daniele
– sequence: 3
  givenname: Giulia
  surname: Di Muzio
  fullname: Di Muzio, Giulia
– sequence: 4
  givenname: Luca
  surname: Triboli
  fullname: Triboli, Luca
– sequence: 5
  givenname: Piergiuseppe
  orcidid: 0000-0002-2632-1473
  surname: De Rosa
  fullname: De Rosa, Piergiuseppe
– sequence: 6
  givenname: Giovanni
  surname: Perini
  fullname: Perini, Giovanni
– sequence: 7
  givenname: Federico M.
  orcidid: 0000-0002-7325-9908
  surname: Giorgi
  fullname: Giorgi, Federico M.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32429325$$D View this record in MEDLINE/PubMed
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Keywords gene networks
phylogenesis
epigenomics
histone deacetylases
HDAC inhibitors
cancer
chromatin
HDACi
epigenetics
HDAC
Language English
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Snippet Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors,...
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SubjectTerms antineoplastic agents
Antineoplastic Agents - therapeutic use
Arthropods
Cell cycle
Chelonia mydas
chromatin
Chromatin remodeling
Enzymes
Eukaryotes
Evolutionary conservation
Gene expression
Genomes
HDAC protein
Histone deacetylase
Histone Deacetylase Inhibitors - therapeutic use
Histone Deacetylases - genetics
Histones
Histones - genetics
Humans
Insects
Mammals
moieties
Nematodes
Neoplasms - genetics
Neoplasms - therapy
Organisms
Pathogenesis
Phylogenetics
Proteins
Reptiles & amphibians
Review
Substrate Specificity - genetics
tissues
Transcription
transcription (genetics)
Transcription Factors - genetics
Yeast
Zebrafish
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Title Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
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Volume 11
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