GGCX and VKORC1 inhibit osteocalcin endocrine functions

• Published in: The Journal of cell biology Vol. 208; no. 6; pp. 761 - 776
• Main Authors: Ferron, Mathieu, Lacombe, Julie, Germain, Amélie, Oury, Franck, Karsenty, Gérard
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 16.03.2015; The Rockefeller University Press
• Subjects: Animals; Biochemistry; Brain; Carbon-Carbon Ligases - physiology; Cell Communication; Cells, Cultured; Diet, High-Fat - adverse effects; Enzymes; Female; Fertility; Glucose; Glucose - metabolism; Glucose Intolerance; Homeostasis; Hormones; Inactivation; Insulin Resistance; Male; Membrane Proteins - physiology; Mice, Transgenic; Obesity - etiology; Obesity - metabolism; Osteoblasts; Osteocalcin - physiology; Protein Processing, Post-Translational; Vitamin K Epoxide Reductases - physiology

Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy expenditure, male fertility, brain development, and cognition. Before being secreted by osteoblasts in the bone extracellular matrix, OCN is γ-carboxylated by the γ-carboxylase (GGCX) on three glutamic acid resid...