Dexmedetomidine may upregulate the expression of caveolin-1 in lung tissues of rats with sepsis and improve the short-term outcome - Zhang, Yun; Ran, Ke; Zhang, Shu-Bin; Jiang, Lili; Wang, Dan; Li, Zhi-Jian (Molecular medicine reports, 2017)
Keywords: Abdomen; Adrenergic alpha-2 Receptor Antagonists - pharmacology; Adrenergic alpha-2 Receptor Antagonists - therapeutic use; Adrenergic receptors; Animals; Blood Gas Analysis; Body temperature; Body Temperature - drug effects; Care and treatment; Caveolin; Caveolin 1 - genetics; Caveolin 1 - metabolism; Caveolin-1; Caveolins; Cecum; Dexmedetomidine; Dexmedetomidine - pharmacology; Disease Models, Animal; Endocytosis; FDA approval; Hospitals; Hypnotics and Sedatives - pharmacology; Imidazoles; Imidazoles - pharmacology; Imidazoles - therapeutic use; Imidazoline; Inflammation; Kinases; Laboratories; Lactic acid; Lung - metabolism; Lung - pathology; Macrophages; Male; Metabolic pathways; Nitric oxide; Phosphorylation; Proteins; Rats; Rats, Sprague-Dawley; Rodents; secondary lung injury; Sepsis; Sepsis - drug therapy; Sepsis - mortality; Sepsis - pathology; signaling crosstalk; Studies; Surgery; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Up-Regulation - drug effects; United States--US; China