Dynamics of telomere erosion in transformed and non-transformed avian cells in vitro

• Published in: Cytogenetic and Genome Research Vol. 102; no. 1-4; pp. 318 - 325
• Main Authors: Swanberg, S.E., Delany, M.E.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2003
• Subjects: Animals; B-Lymphocytes - chemistry; B-Lymphocytes - enzymology; B-Lymphocytes - metabolism; B-Lymphocytes - pathology; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Chick Embryo; Chickens - genetics; Chromosomal Instability - genetics; Fibroblasts - chemistry; Fibroblasts - enzymology; Fibroblasts - metabolism; Fibroblasts - pathology; Gallus gallus; Hepatocytes - chemistry; Hepatocytes - enzymology; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Kidney - cytology; Kidney - embryology; Kidney - enzymology; Macrophages - chemistry; Macrophages - enzymology; Macrophages - metabolism; Macrophages - pathology; Quail - embryology; Quail - genetics; T-Lymphocytes - chemistry; T-Lymphocytes - enzymology; T-Lymphocytes - metabolism; T-Lymphocytes - pathology; Telomerase - metabolism; Telomere - genetics; Turkeys - embryology; Turkeys - genetics

Although vertebrate telomeres are highly conserved, telomere dynamics and telomerase profiles vary among species. The objective of the present study was to examine telomerase activity and telomere length profiles of transformed and non-transformed avian cells in vitro. Non-transformed chicken embryo...