Inorganic/Biopolymers Hybrid Hydrogels Dual Cross-Linked for Bone Tissue Regeneration

In tissue engineering, the potential of re-growing new tissue has been considered, however, developments towards such clinical and commercial outcomes have been modest. One of the most important elements here is the selection of a biomaterial that serves as a "scaffold" for the regeneratio...

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Published inGels Vol. 8; no. 12; p. 762
Main Authors Cernencu, Alexandra I, Dinu, Andreea I, Dinescu, Sorina, Trușcă, Roxana, Istodorescu, Mircea, Lungu, Adriana, Stancu, Izabela C, Iovu, Horia
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.11.2022
MDPI
Subjects
3-dimensional reinforcement
Biocompatibility
Biological products
Biomedical materials
Biomimetics
Biopolymers
Bones
Cellulose
Cellulose fibers
Conjugation
Crosslinked polymers
Crosslinking
Deformation
Design
Gelatin
Hydrogels
Investigations
Mechanical properties
Mineralization
Modulus of elasticity
Nanocomposites
Nanofibers
Nanoparticles
nanostructures
Natural polymers
Pectin
Photochemical reactions
polymer–matrix composites
Polysaccharides
Proteins
Regeneration (physiology)
Scaffolding
Silicon compounds
Tissue engineering
Romania
nanostructures
polymer–matrix composites
3-dimensional reinforcement
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Abstract In tissue engineering, the potential of re-growing new tissue has been considered, however, developments towards such clinical and commercial outcomes have been modest. One of the most important elements here is the selection of a biomaterial that serves as a "scaffold" for the regeneration process. Herein, we designed hydrogels composed of two biocompatible natural polymers, namely gelatin with photopolymerizable functionalities and a pectin derivative amenable to direct protein conjugation. Aiming to design biomimetic hydrogels for bone regeneration, this study proposes double-reinforcement by way of inorganic/biopolymer hybrid filling composed of Si-based compounds and cellulose nanofibers. To attain networks with high flexibility and elastic modulus, a double-crosslinking strategy was envisioned-photochemical and enzyme-mediated conjugation reactions. The dual cross-linked procedure will generate intra- and intermolecular interactions between the protein and polysaccharide and might be a resourceful strategy to develop innovative scaffolding materials.
AbstractList In tissue engineering, the potential of re-growing new tissue has been considered, however, developments towards such clinical and commercial outcomes have been modest. One of the most important elements here is the selection of a biomaterial that serves as a “scaffold” for the regeneration process. Herein, we designed hydrogels composed of two biocompatible natural polymers, namely gelatin with photopolymerizable functionalities and a pectin derivative amenable to direct protein conjugation. Aiming to design biomimetic hydrogels for bone regeneration, this study proposes double-reinforcement by way of inorganic/biopolymer hybrid filling composed of Si-based compounds and cellulose nanofibers. To attain networks with high flexibility and elastic modulus, a double-crosslinking strategy was envisioned—photochemical and enzyme-mediated conjugation reactions. The dual cross-linked procedure will generate intra- and intermolecular interactions between the protein and polysaccharide and might be a resourceful strategy to develop innovative scaffolding materials.
Audience Academic
Author Cernencu, Alexandra I
Iovu, Horia
Istodorescu, Mircea
Trușcă, Roxana
Stancu, Izabela C
Dinescu, Sorina
Dinu, Andreea I
Lungu, Adriana
AuthorAffiliation 3 Research Institute of the University of Bucharest, University of Bucharest, 05066 București, Romania
1 Advanced Polymer Materials Group, University Politehnica of Bucharest, 060042 București, Romania
4 University Politehnica of Bucharest, 060042 București, Romania
2 Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 București, Romania
5 S.C. Medical Ortovit SRL, 011098 București, Romania
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Keywords nanostructures
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3-dimensional reinforcement
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SSID ssj0001753511
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Snippet In tissue engineering, the potential of re-growing new tissue has been considered, however, developments towards such clinical and commercial outcomes have...
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StartPage 762
SubjectTerms 3-dimensional reinforcement
Biocompatibility
Biological products
Biomedical materials
Biomimetics
Biopolymers
Bones
Cellulose
Cellulose fibers
Conjugation
Crosslinked polymers
Crosslinking
Deformation
Design
Gelatin
Hydrogels
Investigations
Mechanical properties
Mineralization
Modulus of elasticity
Nanocomposites
Nanofibers
Nanoparticles
nanostructures
Natural polymers
Pectin
Photochemical reactions
polymer–matrix composites
Polysaccharides
Proteins
Regeneration (physiology)
Scaffolding
Silicon compounds
Tissue engineering
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Title Inorganic/Biopolymers Hybrid Hydrogels Dual Cross-Linked for Bone Tissue Regeneration
URI https://www.ncbi.nlm.nih.gov/pubmed/36547286
https://www.proquest.com/docview/2756699666/abstract/
https://search.proquest.com/docview/2757054034
https://pubmed.ncbi.nlm.nih.gov/PMC9777565
https://doaj.org/article/8680abf4e6324255bd97889dc3d73884
Volume 8
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