Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity

• Published in: Dermatology research and practice Vol. 2022; no. 1; p. 5004642
• Main Authors: Sayed Mahmoud Marie, Radwa El, Abd El-Fadeel, Noha M., El-Sayed Marei, Yara, Atef, Lina M.
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 2022; John Wiley & Sons, Inc; Wiley
• Subjects: Age; Alopecia; Antigens; Autoimmune diseases; Autoimmunity; Baldness; Biopsy; CD27 antigen; CD70 antigen; Cell activation; Cell survival; Cytokines; Cytotoxicity; Disease; Family medical history; Follicles; Gene expression; Hair; Hair loss; Immunological tolerance; Lesions; Lymphocytes; Lymphocytes T; Patients; Polymerase chain reaction; Scalp; Standard deviation; Statistical analysis; Tumor necrosis factor-TNF; United Kingdom > UK; Suez Canal; United States > US; Egypt

Background. Alopecia areata (AA) is an acquired hair loss disorder induced by a cell-mediated autoimmune attack against anagen hair follicles. CD27-CD70 is a receptor-ligand complex which enhances T helper and cytotoxic T cell activation, survival, and proliferation. The overstimulation of this comp...