Increasing cumulative exposure to volatile anesthetic agents is associated with poorer neurodevelopmental outcomes in children with hypoplastic left heart syndrome

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 152; no. 2; pp. 482 - 489
• Main Authors: Diaz, Laura K., MD, Gaynor, J. William, MD, Koh, Shannon J., BA, Ittenbach, Richard F., PhD, Gerdes, Marsha, PhD, Bernbaum, Judy C., MD, Zackai, Elaine H., MD, Clancy, Robert R., MD, Rehman, Mohamed A., MD, Pennington, Jeffrey W., BS, Burnham, Nancy, MSN, Spray, Thomas L., MD, Nicolson, Susan C., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016
• Subjects: anesthesia; Cardiothoracic Surgery; congenital heart surgery; neurodevelopment; neurotoxicity; BSID-II; SES; NP; hypoplastic left heart syndrome; full-scale IQ; WPPSI-III; deep hypothermic circulatory arrest; CNS; general anesthesia; neurodevelopmental; anesthesia; AUC; AIMS; neurotoxicity; neurodevelopment; FSIQ; Apolipoprotein E; verbal IQ; cardiopulmonary bypass; GA; intensive care unit; APOE; performance IQ; minimum alveolar concentration hours; volatile anesthetic agents; HLHS; central nervous system; Wechsler Preschool and Primary Scale of Intelligence, 3rd edition; LOS; CPB; congenital heart surgery; ND; VAA; length of stay; PIQ; ICU; MAC-hrs; Bayley Scales of Infant Development-II; HC; head circumference; DHCA; socioeconomic status; Anesthesia Information Management System; area-under-the-curve; CHD; nasopharyngeal; congenital heart defects; VIQ

Abstract Objectives Despite improved survival in children with hypoplastic left heart syndrome (HLHS), significant concern persists regarding their neurodevelopmental (ND) outcomes. Previous studies have identified patient factors, such as prematurity and genetic syndromes, to be associated with wor...