Pathological and virological findings of type I interferon receptor knockout mice upon experimental infection with Heartland virus

• Published in: Virus research Vol. 340; p. 199301
• Main Authors: Fujii, Hikaru, Fukushi, Shuetsu, Yoshikawa, Tomoki, Nagata, Noriyo, Taniguchi, Satoshi, Shimojima, Masayuki, Yamada, Souichi, Tani, Hideki, Uda, Akihiko, Maeki, Takahiro, Harada, Shizuko, Kurosu, Takeshi, Lim, Chang Kweng, Nakayama, Eri, Takayama-Ito, Mutsuyo, Watanabe, Shumpei, Ebihara, Hideki, Morikawa, Shigeru, Saijo, Masayuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.02.2024
• Subjects: Animal model; blood; chemokines; digestive tract; disease severity; Heartland virus; IFNAR-/- mice; interferons; interleukin-10; intestines; kidneys; liver; lungs; lymph; lymph nodes; Pathogenesis; pathophysiology; RNA; spleen; stomach; tumor necrosis factors; viruses; Heartland virus; pathogenesis; animal model; IFNAR(−/−) mice

Heartland virus (HRTV) causes generalized symptoms, severe shock, and multiple organ failure. We previously reported that interferon-α/β receptor knockout (IFNAR ) mice infected intraperitoneally with 1 × 10 tissue culture-infective dose (TCID ) of HRTV died, while those subcutaneously infected with...