Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells

• Published in: The Journal of cell biology Vol. 215; no. 1; pp. 121 - 138
• Main Authors: Kunii, Masataka, Ohara-Imaizumi, Mica, Takahashi, Noriko, Kobayashi, Masaki, Kawakami, Ryosuke, Kondoh, Yasumitsu, Shimizu, Takeshi, Simizu, Siro, Lin, Bangzhong, Nunomura, Kazuto, Aoyagi, Kyota, Ohno, Mitsuyo, Ohmuraya, Masaki, Sato, Takashi, Yoshimura, Shin-Ichiro, Sato, Ken, Harada, Reiko, Kim, Yoon-Jeong, Osada, Hiroyuki, Nemoto, Tomomi, Kasai, Haruo, Kitamura, Tadahiro, Nagamatsu, Shinya, Harada, Akihiro
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 10.10.2016; The Rockefeller University Press
• Subjects: Acinar Cells - metabolism; Acinar Cells - ultrastructure; Amylases - metabolism; Animals; Cell Fusion; Cells; Cellular biology; Enzymes; Exocytosis; Glucose Transporter Type 4 - metabolism; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - cytology; Membranes; Mice, Knockout; Microscopy, Fluorescence, Multiphoton; Models, Biological; Molecular weight; Pancreas, Exocrine - cytology; Parotid Gland - cytology; Protein Transport; Proteins; Qb-SNARE Proteins - deficiency; Qb-SNARE Proteins - metabolism; Qc-SNARE Proteins - deficiency; Qc-SNARE Proteins - metabolism; Secretory Vesicles - metabolism; SNARE Proteins - metabolism; Synaptosomal-Associated Protein 25 - metabolism

The membrane fusion of secretory granules with plasma membranes is crucial for the exocytosis of hormones and enzymes. Secretion disorders can cause various diseases such as diabetes or pancreatitis. Synaptosomal-associated protein 23 (SNAP23), a soluble N-ethyl-maleimide sensitive fusion protein at...