Prediction of imminent, severe deterioration of children with parallel circulations using real-time processing of physiologic data
Abstract Objectives Sudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary circulation from a common ventricular chamber. It is hypothesized that unforeseen acute deterioration is preceded by subtle changes in physiologic d...
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Published in | The Journal of thoracic and cardiovascular surgery Vol. 152; no. 1; pp. 171 - 177 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.07.2016
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Abstract | Abstract Objectives Sudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary circulation from a common ventricular chamber. It is hypothesized that unforeseen acute deterioration is preceded by subtle changes in physiologic dynamics before overt clinical extremis. Our objective was to develop a computer algorithm to automatically recognize precursors to deterioration in real-time, providing an early warning to care staff. Methods Continuous high-resolution physiologic recordings were obtained from 25 children with parallel systemic and pulmonary circulation who were admitted to the cardiovascular intensive care unit of Texas Children's Hospital between their early neonatal palliation and stage 2 surgical palliation. Instances of cardiorespiratory deterioration (defined as the need for cardiopulmonary resuscitation or endotracheal intubation) were found via a chart review. A classification algorithm was applied to both primary and derived parameters that were significantly associated with deterioration. The algorithm was optimized to discriminate predeterioration physiology from stable physiology. Results Twenty cardiorespiratory deterioration events were identified in 13 of the 25 infants. The resulting algorithm was both sensitive and specific for detecting impending events, 1 to 2 hours in advance of overt extremis (receiver operating characteristic area = 0.91, 95% confidence interval = 0.88-0.94). Conclusions Automated, intelligent analysis of standard physiologic data in real-time can detect signs of clinical deterioration too subtle for the clinician to observe without the aid of a computer. This metric may serve as an early warning indicator of critical deterioration in patients with parallel systemic and pulmonary circulation. |
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AbstractList | Sudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary circulation from a common ventricular chamber. It is hypothesized that unforeseen acute deterioration is preceded by subtle changes in physiologic dynamics before overt clinical extremis. Our objective was to develop a computer algorithm to automatically recognize precursors to deterioration in real-time, providing an early warning to care staff.
Continuous high-resolution physiologic recordings were obtained from 25 children with parallel systemic and pulmonary circulation who were admitted to the cardiovascular intensive care unit of Texas Children's Hospital between their early neonatal palliation and stage 2 surgical palliation. Instances of cardiorespiratory deterioration (defined as the need for cardiopulmonary resuscitation or endotracheal intubation) were found via a chart review. A classification algorithm was applied to both primary and derived parameters that were significantly associated with deterioration. The algorithm was optimized to discriminate predeterioration physiology from stable physiology.
Twenty cardiorespiratory deterioration events were identified in 13 of the 25 infants. The resulting algorithm was both sensitive and specific for detecting impending events, 1 to 2 hours in advance of overt extremis (receiver operating characteristic area = 0.91, 95% confidence interval = 0.88-0.94).
Automated, intelligent analysis of standard physiologic data in real-time can detect signs of clinical deterioration too subtle for the clinician to observe without the aid of a computer. This metric may serve as an early warning indicator of critical deterioration in patients with parallel systemic and pulmonary circulation. Abstract Objectives Sudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary circulation from a common ventricular chamber. It is hypothesized that unforeseen acute deterioration is preceded by subtle changes in physiologic dynamics before overt clinical extremis. Our objective was to develop a computer algorithm to automatically recognize precursors to deterioration in real-time, providing an early warning to care staff. Methods Continuous high-resolution physiologic recordings were obtained from 25 children with parallel systemic and pulmonary circulation who were admitted to the cardiovascular intensive care unit of Texas Children's Hospital between their early neonatal palliation and stage 2 surgical palliation. Instances of cardiorespiratory deterioration (defined as the need for cardiopulmonary resuscitation or endotracheal intubation) were found via a chart review. A classification algorithm was applied to both primary and derived parameters that were significantly associated with deterioration. The algorithm was optimized to discriminate predeterioration physiology from stable physiology. Results Twenty cardiorespiratory deterioration events were identified in 13 of the 25 infants. The resulting algorithm was both sensitive and specific for detecting impending events, 1 to 2 hours in advance of overt extremis (receiver operating characteristic area = 0.91, 95% confidence interval = 0.88-0.94). Conclusions Automated, intelligent analysis of standard physiologic data in real-time can detect signs of clinical deterioration too subtle for the clinician to observe without the aid of a computer. This metric may serve as an early warning indicator of critical deterioration in patients with parallel systemic and pulmonary circulation. OBJECTIVESSudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary circulation from a common ventricular chamber. It is hypothesized that unforeseen acute deterioration is preceded by subtle changes in physiologic dynamics before overt clinical extremis. Our objective was to develop a computer algorithm to automatically recognize precursors to deterioration in real-time, providing an early warning to care staff. METHODSContinuous high-resolution physiologic recordings were obtained from 25 children with parallel systemic and pulmonary circulation who were admitted to the cardiovascular intensive care unit of Texas Children's Hospital between their early neonatal palliation and stage 2 surgical palliation. Instances of cardiorespiratory deterioration (defined as the need for cardiopulmonary resuscitation or endotracheal intubation) were found via a chart review. A classification algorithm was applied to both primary and derived parameters that were significantly associated with deterioration. The algorithm was optimized to discriminate predeterioration physiology from stable physiology. RESULTSTwenty cardiorespiratory deterioration events were identified in 13 of the 25 infants. The resulting algorithm was both sensitive and specific for detecting impending events, 1 to 2 hours in advance of overt extremis (receiver operating characteristic area = 0.91, 95% confidence interval = 0.88-0.94). CONCLUSIONSAutomated, intelligent analysis of standard physiologic data in real-time can detect signs of clinical deterioration too subtle for the clinician to observe without the aid of a computer. This metric may serve as an early warning indicator of critical deterioration in patients with parallel systemic and pulmonary circulation. |
Author | Brady, Ken M., MD Bavare, Aarti C., MD, MPH Patterson, Lance W., BS Shekerdemian, Lara S., MD Penny, Daniel J., MD, PhD, MHA Acosta, Sebastian I., PhD Vu, Eric L., MD Rusin, Craig G., PhD Myers, Risa B., MS |
AuthorAffiliation | 4 Department of Computer Science, Rice University 1 Department of Pediatrics - Cardiology, Baylor College of Medicine, Texas Children’s Hospital 3 Department of Pediatrics - Anesthesia, Baylor College of Medicine, Texas Children’s Hospital 2 Department of Pediatrics - Critical Care, Baylor College of Medicine, Texas Children’s Hospital |
AuthorAffiliation_xml | – name: 2 Department of Pediatrics - Critical Care, Baylor College of Medicine, Texas Children’s Hospital – name: 1 Department of Pediatrics - Cardiology, Baylor College of Medicine, Texas Children’s Hospital – name: 3 Department of Pediatrics - Anesthesia, Baylor College of Medicine, Texas Children’s Hospital – name: 4 Department of Computer Science, Rice University |
Author_xml | – sequence: 1 fullname: Rusin, Craig G., PhD – sequence: 2 fullname: Acosta, Sebastian I., PhD – sequence: 3 fullname: Shekerdemian, Lara S., MD – sequence: 4 fullname: Vu, Eric L., MD – sequence: 5 fullname: Bavare, Aarti C., MD, MPH – sequence: 6 fullname: Myers, Risa B., MS – sequence: 7 fullname: Patterson, Lance W., BS – sequence: 8 fullname: Brady, Ken M., MD – sequence: 9 fullname: Penny, Daniel J., MD, PhD, MHA |
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Keywords | SpO 2 CPR hypoplastic left heart syndrome single ventricle institutional review board cardiovascular intensive care unit cardiopulmonary resuscitation electrocardiogram extracorporeal membrane oxygenation intensive care unit receiver operating characteristic ECMO Texas Children's Hospital peripheral capillary oxygen saturation predictive analytics ROC ECG BCM HLHS CVICU critical deterioration IRB TCH Baylor College of Medicine ICU SpO2 |
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Snippet | Abstract Objectives Sudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary... Sudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary circulation from a common... OBJECTIVESSudden death is common in patients with hypoplastic left heart syndrome and comparable lesions with parallel systemic and pulmonary circulation from... |
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SubjectTerms | Algorithms Cardiopulmonary Resuscitation Cardiothoracic Surgery Child Child, Preschool critical deterioration Female Follow-Up Studies Hospitalization - trends Humans Hypoplastic Left Heart Syndrome - diagnosis Hypoplastic Left Heart Syndrome - physiopathology Hypoplastic Left Heart Syndrome - surgery Infant Intensive Care Units, Pediatric Male Monitoring, Physiologic - methods predictive analytics Prospective Studies Pulmonary Circulation - physiology ROC Curve single ventricle Texas Time Factors |
Title | Prediction of imminent, severe deterioration of children with parallel circulations using real-time processing of physiologic data |
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