High-Resolution DNA Copy Number Profiling of Malignant Peripheral Nerve Sheath Tumors Using Targeted Microarray-Based Comparative Genomic Hybridization

• Published in: Clinical cancer research Vol. 14; no. 4; pp. 1015 - 1024
• Main Authors: Mantripragada, Kiran K., Spurlock, Gillian, Kluwe, Lan, Chuzhanova, Nadia, Ferner, Rosalie E., Frayling, Ian M., Dumanski, Jan P., Guha, Abhijit, Mautner, Victor, Upadhyaya, Meena
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.02.2008
• Subjects: Antineoplastic agents; array CGH; Biological and medical sciences; Biomarkers, Tumor - genetics; Gene Dosage; Gene Expression Profiling; Humans; Image Processing, Computer-Assisted; Medical sciences; microarray; MPNST; Nerve Sheath Neoplasms - genetics; Neurofibroma - genetics; neurofibromatosis; Neurofibromatosis 1 - complications; Neurofibromatosis 1 - genetics; Neurology; NF1; Oligonucleotide Array Sequence Analysis; Pharmacology. Drug treatments; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Tumors of the nervous system. Phacomatoses; Peripheral nerve; Nervous system diseases; High resolution; Targeting; Copy number; Neurinoma; Malignant tumor; Gene expression; Target; Comparative genomic hybridization; DNA; Benign neoplasm; Cancer

Purpose: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition that predisposes to benign and malignant tumors. The lifetime risk of a malignant peripheral nerve sheath tumor (MPNST) in NF1 is ∼10%. These tumors have a poor survival rate and their molecular basis remains unclear. We repo...