Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis

• Published in: International journal of molecular sciences Vol. 13; no. 12; pp. 16373 - 16386
• Main Authors: Lehman, Jason A, Mayo, Lindsey D
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 03.12.2012; Molecular Diversity Preservation International (MDPI)
• Subjects: Animals; Base excision repair; Cancer; Carcinogenesis - genetics; Chemotherapy; DNA damage; DNA Damage - genetics; DNA Mismatch Repair; DNA repair; DNA Repair - genetics; genomics; Homologous Recombination; Humans; Integration; MDM2 protein; mismatch repair; murine double minute-2; Non-homologous end joining; Nucleotide excision repair; Oncogenes; p53 protein; Proto-Oncogene Proteins c-mdm2 - physiology; Review; Signal Transduction - genetics; Tumor suppressor genes; Tumorigenesis

The alteration of tumorigenic pathways leading to cancer is a degenerative disease process typically involving inactivation of tumor suppressor proteins and hyperactivation of oncogenes. One such oncogenic protein product is the murine double-minute 2, or Mdm2. While, Mdm2 has been primarily associa...