Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants

• Published in: The Journal of pediatrics Vol. 174; pp. 52 - 56
• Main Authors: Rhee, Christopher J., MD, Kaiser, Jeffrey R., MD, MA, Rios, Danielle R., MD, Kibler, Kathleen K., CCP, Easley, R. Blaine, MD, Andropoulos, Dean B., MD, Czosnyka, Marek, PhD, Smielewski, Peter, PhD, Varsos, Georgios V., PhD, Rusin, Craig G., PhD, Gauss, C. Heath, MS, Williams, D. Keith, PhD, MPH, Brady, Ken M., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016
• Subjects: arterial blood pressure; Blood Flow Velocity - physiology; Blood Pressure - physiology; cerebral blood flow; Cerebral Hemorrhage - etiology; Cerebral Hemorrhage - physiopathology; Cohort Studies; critical closing pressure; Diastole; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - etiology; Infant, Premature, Diseases - physiopathology; Male; Middle Cerebral Artery - physiology; Pediatrics; Respiration, Artificial; Umbilical Arteries - physiology; CBF; NICU; Intraventricular hemorrhage; Diastolic closing margin; Cerebral blood flow velocity; Estimated gestational age; ABP; DCM; CBFV; arterial blood pressure; critical closing pressure; Neonatal intensive care unit; cerebral blood flow; IVH; CrCP; EGA

Objective To determine whether the diastolic closing margin (DCM), defined as diastolic blood pressure minus critical closing pressure, is associated with the development of early severe intraventricular hemorrhage (IVH). Study design A reanalysis of prospectively collected data was conducted. Prema...