Lymphocytes of patients with Alzheimer's disease display different DNA damage repair kinetics and expression profiles of DNA repair and stress response genes

• Published in: International journal of molecular sciences Vol. 14; no. 6; pp. 12380 - 12400
• Main Authors: Leandro, Giovana S, Lobo, Romulo R, Oliveira, Douglas V N P, Moriguti, Julio C, Sakamoto-Hojo, Elza T
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.06.2013; Molecular Diversity Preservation International (MDPI)
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Brain; Case-Control Studies; Cells, Cultured; Comet Assay; Disease; DNA damage; DNA Damage - genetics; DNA repair; DNA Repair - genetics; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Hydrogen peroxide; Hypotheses; Kinetics; Lymphocytes; Lymphocytes - metabolism; Male; Mitochondrial DNA; Mutation; Oxidative stress; Pathogenesis; Pathophysiology; Signal transduction; Stress, Physiological - genetics; Superoxide Dismutase - metabolism; Tumor Suppressor Protein p53 - metabolism; Brazil

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by loss of memory and cognitive capacity. Given the limitations to analyze brain cells, it is important to study whether peripheral lymphocytes can provide biological markers for AD, an interesting approach, onc...