Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 110; no. 3; p. 858
• Main Authors: Noé, B, Schliess, F, Wettstein, M, Heinrich, S, Häussinger, D
• Format: Journal Article
• Language: English
• Published: United States 01.03.1996
• Subjects: Animals; Bile - metabolism; Calcium-Calmodulin-Dependent Protein Kinases - metabolism; Cells, Cultured; Enzyme Activation; Liver - cytology; Liver - enzymology; Liver - metabolism; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osmolar Concentration; Protein-Tyrosine Kinases - metabolism; Rats; Rats, Wistar; Signal Transduction; Taurocholic Acid - metabolism

Hypo-osmotic cell swelling increases the capacity of taurocholate excretion into bile in the perfused rat liver. The aim of this study was to clarify the mechanisms linking cell swelling to bile acid secretion. The influence of hypo-osmotic cell swelling on intracellular signal transduction and bile...