Hide and seek: interplay between influenza viruses and B cells

• Published in: International immunology Vol. 32; no. 9; pp. 605 - 611
• Main Authors: Kuraoka, Masayuki, Adachi, Yu, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 08.09.2020
• Subjects: B-Lymphocytes - immunology; Hemagglutinins - immunology; Humans; Invited Reviews; Orthomyxoviridae - immunology; Receptors, Antigen, B-Cell - immunology; germinal centers; occluded epitope; broadly protective antibodies; B-cell responses

Abstract Influenza virus constantly acquires genetic mutations/reassortment in the major surface protein, hemagglutinin (HA), resulting in the generation of strains with antigenic variations. There are, however, HA epitopes that are conserved across influenza viruses and are targeted by broadly prot...