Elucidating the metabolic characteristics of pancreatic β-cells from patients with type 2 diabetes (T2D) using a genome-scale metabolic modeling

• Published in: Computers in biology and medicine Vol. 144; p. 105365
• Main Authors: Paul, Abhijit, Azhar, Salman, Das, Phonindra Nath, Bairagi, Nandadulal, Chatterjee, Samrat
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.05.2022; Elsevier Limited
• Subjects: Antioxidants; Beta cells; Cardiovascular diseases; Coupling; Coupling factors; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Endoplasmic reticulum; Fatty acids; Fatty Acids - metabolism; Gene expression; Genetic variation; Genome scale models of metabolism; Genomes; Glucose - metabolism; Heart diseases; Humans; Hyperglycemia; Insulin; Insulin - metabolism; Insulin resistance; Insulin secretion; Insulin-Secreting Cells; Internal Medicine; Metabolic flux; Metabolism; Metabolites; Mitochondria; Mitochondria - metabolism; Mitochondrial metabolism; Modelling; Other; Oxidation; Oxidative phosphorylation; Pancreas; Pathogenesis; Phosphorylation; Proteins; Public health; Reactive oxygen species; Secretion; Genome scale models of metabolism; Mitochondrial metabolism; Oxidative phosphorylation; Genetic variation; Coupling factors; Insulin secretion

Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate insulin. Despite extensive research, the identity of factors contributing to the dysregulated metabolism-secretion coupling in the β-cells remains elusive. The present study attempts to ca...